Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation

被引：235

作者：

Hoffmann, Thomas J. ^{[1
,2
]}

Ehret, Georg B. ^{[3
,4
]}

Nandakumar, Priyanka ^{[3
]}

Ranatunga, Dilrini ^{[5
]}

Schaefer, Catherine ^{[5
]}

Kwok, Pui-Yan ^{[2
]}

Iribarren, Carlos ^{[5
]}

Chakravarti, Aravinda ^{[3
]}

Risch, Neil ^{[1
,2
,5
]}

机构：

[1] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Inst Human Genet, San Francisco, CA 94143 USA

[3] McKusick Nathans Inst Genet Med, Ctr Complex Dis Gen, Baltimore, MD USA

[4] Univ Geneva, Dept Specialties Internal Med, Cardiol, Geneva, Switzerland

[5] Kaiser Permanente Northern Calif Div Res, Oakland, CA USA

来源：

NATURE GENETICS | 2017年 / 49卷 / 01期

关键词：

PULSE PRESSURE; MEAN ARTERIAL; GENETIC-LOCI; METAANALYSIS; VARIANTS; TRAITS; COMMON; INDIVIDUALS; AFRICAN; HYPERTENSION;

D O I：

10.1038/ng.3715

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Longitudinal electronic health records on 99,785 Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort individuals provided 1,342,814 systolic and diastolic blood pressure measurements for a genome-wide association study on long-term average systolic, diastolic, and pulse pressure. We identified 39 new loci among 75 genome-wide significant loci (P <= 5 x 10(-8)), with most replicating in the combined International Consortium for Blood Pressure (ICBP; n = 69,396) and UK Biobank (UKB; n = 152,081) studies. Combining GERA with ICBP yielded 36 additional new loci, with most replicating in UKB. Combining all three studies (n = 321,262) yielded 241 additional genome-wide significant loci, although no replication sample was available for these. All associated loci explained 2.9%, 2.5%, and 3.1 % of variation in systolic, diastolic, and pulse pressure, respectively, in GERA non-Hispanic whites. Using multiple blood pressure measurements in GERA doubled the variance explained. A normalized risk score was associated with time to onset of hypertension (hazards ratio = 1.18, P = 8.2 x 10(-45)). Expression quantitative trait locus analysis of blood pressure loci showed enrichment in aorta and tibial artery.

引用

页码：54 / 64

页数：11

共 44 条

[1] The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans [J].

Ardlie, Kristin G. ;

DeLuca, David S. ;

Segre, Ayellet V. ;

Sullivan, Timothy J. ;

Young, Taylor R. ;

Gelfand, Ellen T. ;

Trowbridge, Casandra A. ;

Maller, Julian B. ;

Tukiainen, Taru ;

Lek, Monkol ;

Ward, Lucas D. ;

Kheradpour, Pouya ;

Iriarte, Benjamin ;

Meng, Yan ;

Palmer, Cameron D. ;

Esko, Tonu ;

Winckler, Wendy ;

Hirschhorn, Joel N. ;

Kellis, Manolis ;

MacArthur, Daniel G. ;

Getz, Gad ;

Shabalin, Andrey A. ;

Li, Gen ;

Zhou, Yi-Hui ;

Nobel, Andrew B. ;

Rusyn, Ivan ;

Wright, Fred A. ;

Lappalainen, Tuuli ;

Ferreira, Pedro G. ;

Ongen, Halit ;

Rivas, Manuel A. ;

Battle, Alexis ;

Mostafavi, Sara ;

Monlong, Jean ;

Sammeth, Michael ;

Mele, Marta ;

Reverter, Ferran ;

Goldmann, Jakob M. ;

Koller, Daphne ;

Guigo, Roderic ;

McCarthy, Mark I. ;

Dermitzakis, Emmanouil T. ;

Gamazon, Eric R. ;

Im, Hae Kyung ;

Konkashbaev, Anuar ;

Nicolae, Dan L. ;

Cox, Nancy J. ;

Flutre, Timothee ;

Wen, Xiaoquan ;

Stephens, Matthew .

SCIENCE, 2015, 348 (6235) :648-660

[2] Estimating her tability of complex traits from genonne-wide association studies using IBS-based Haseman-Elston regression [J].

Chen, Guo-Bo .

FRONTIERS IN GENETICS, 2014, 5

[3] Model-free Estimation of Recent Genetic Relatedness [J].

Conomos, Matthew P. ;

Reiner, Alexander P. ;

Weir, Bruce S. ;

Thornton, Timothy A. .

AMERICAN JOURNAL OF HUMAN GENETICS, 2016, 98 (01) :127-148

[4] Genomic control for association studies [J].

Devlin, B ;

Roeder, K .

BIOMETRICS, 1999, 55 (04) :997-1004

[5] The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals [J].

Ehret, Georg B. ;

Ferreira, Teresa ;

Chasman, Daniel I. ;

Jackson, Anne U. ;

Schmidt, Ellen M. ;

Johnson, Toby ;

Thorleifsson, Gudmar ;

Luan, Jian'an ;

Donnelly, Louise A. ;

Kanoni, Stavroula ;

Petersen, Ann -Kristin ;

Pihurl, Vasyl ;

Strawbridge, Rona J. ;

Shungin, Dmitry ;

Hughes, Maria F. ;

Meirelles, Osorio ;

Kaakinen, Marika ;

Bouatia-Naji, Nabila ;

Kristiansson, Kati ;

Shah, Sonia ;

Kleber, Marcus E. ;

Guo, Xiuqing ;

Lyytikainen, Leo-Pekka ;

Fava, Cristiano ;

Eriksson, Nidas ;

Nolte, Ilja M. ;

Magnusson, Patrik K. ;

Salfati, Elias L. ;

Rallidis, Loukianos S. ;

Theusch, Elizabeth ;

Smith, Andrew J. P. ;

Folkersen, Lasse ;

Witkowska, Kate ;

Pers, Tune H. ;

Joehanes, Roby ;

Kim, Stuart K. ;

Lataniotis, Lazaros ;

Jansen, Rick ;

Johnson, Andrew D. ;

Warren, Helen ;

Kim, Young Jin ;

Zhao, Wei ;

Wu, Ying ;

Tayo, Bamidele O. ;

Bochud, Murielle ;

Absher, Devin ;

Adair, Linda S. ;

Amin, Najaf ;

Arkingl, Dan E. ;

Axelsson, Tomas .

NATURE GENETICS, 2016, 48 (10) :1171-1184

[6] Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk [J].

Ehret, Georg B. ;

Munroe, Patricia B. ;

Rice, Kenneth M. ;

Bochud, Murielle ;

Johnson, Andrew D. ;

Chasman, Daniel I. ;

Smith, Albert V. ;

Tobin, Martin D. ;

Verwoert, Germaine C. ;

Hwang, Shih-Jen ;

Pihur, Vasyl ;

Vollenweider, Peter ;

O'Reilly, Paul F. ;

Amin, Najaf ;

Bragg-Gresham, Jennifer L. ;

Teumer, Alexander ;

Glazer, Nicole L. ;

Launer, Lenore ;

Zhao, Jing Hua ;

Aulchenko, Yurii ;

Heath, Simon ;

Sober, Siim ;

Parsa, Afshin ;

Luan, Jian'an ;

Arora, Pankaj ;

Dehghan, Abbas ;

Zhang, Feng ;

Lucas, Gavin ;

Hicks, Andrew A. ;

Jackson, Anne U. ;

Peden, John F. ;

Tanaka, Toshiko ;

Wild, Sarah H. ;

Rudan, Igor ;

Igl, Wilmar ;

Milaneschi, Yuri ;

Parker, Alex N. ;

Fava, Cristiano ;

Chambers, John C. ;

Fox, Ervin R. ;

Kumari, Meena ;

Go, Min Jin ;

van der Harst, Pim ;

Kao, Wen Hong Linda ;

Sjogren, Marketa ;

Vinay, D. G. ;

Alexander, Myriam ;

Tabara, Yasuharu ;

Shaw-Hawkins, Sue ;

Whincup, Peter H. .

NATURE, 2011, 478 (7367) :103-109

[7] Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study [J].

Fox, Ervin R. ;

Young, J. Hunter ;

Li, Yali ;

Dreisbach, Albert W. ;

Keating, Brendan J. ;

Musani, Solomon K. ;

Liu, Kiang ;

Morrison, Alanna C. ;

Ganesh, Santhi ;

Kutlar, Abdullah ;

Ramachandran, Vasan S. ;

Polak, Josef F. ;

Fabsitz, Richard R. ;

Dries, Daniel L. ;

Farlow, Deborah N. ;

Redline, Susan ;

Adeyemo, Adebowale ;

Hirschorn, Joel N. ;

Sun, Yan V. ;

Wyatt, Sharon B. ;

Penman, Alan D. ;

Palmas, Walter ;

Rotter, Jerome I. ;

Townsend, Raymond R. ;

Doumatey, Ayo P. ;

Tayo, Bamidele O. ;

Mosley, Thomas H., Jr. ;

Lyon, Helen N. ;

Kang, Sun J. ;

Rotimi, Charles N. ;

Cooper, Richard S. ;

Franceschini, Nora ;

Curb, J. David ;

Martin, Lisa W. ;

Eaton, Charles B. ;

Kardia, Sharon L. R. ;

Taylor, Herman A. ;

Caulfield, Mark J. ;

Ehret, Georg B. ;

Johnson, Toby ;

Chakravarti, Aravinda ;

Zhu, Xiaofeng ;

Levy, Daniel .

HUMAN MOLECULAR GENETICS, 2011, 20 (11) :2273-2284

[8] Genome-wide Association Analysis of Blood-Pressure Traits in African-Ancestry Individuals Reveals Common Associated Genes in African and Non-African Populations [J].

Franceschini, Nora ;

Fox, Ervin ;

Zhang, Zhaogong ;

Edwards, Todd L. ;

Nalls, Michael A. ;

Sung, Yun Ju ;

Tayo, Bamidele O. ;

Sun, Yan V. ;

Gottesman, Omri ;

Adeyemo, Adebawole ;

Johnson, Andrew D. ;

Young, J. Hunter ;

Rice, Ken ;

Duan, Qing ;

Chen, Fang ;

Li, Yun ;

Tang, Hua ;

Fornage, Myriam ;

Keene, Keith L. ;

Andrews, Jeanette S. ;

Smith, Jennifer A. ;

Fau, Jessica D. ;

Guangfa, Zhang ;

Guo, Wei ;

Liu, Yu ;

Murray, Sarah S. ;

Musani, Solomon K. ;

Srinivasan, Sathanur ;

Edwards, Digna R. Velez ;

Wang, Heming ;

Becker, Lewis C. ;

Bovet, Pascal ;

Bochud, Murielle ;

Broecke, Ulrich ;

Burnier, Michel ;

Carty, Cara ;

Chasman, Daniel I. ;

Ehret, Georg ;

Chen, Wei-Min ;

Chen, Guanjie ;

Chen, Wei ;

Ding, Jingzhong ;

Dreisbach, Albert W. ;

Evans, Michele K. ;

Guo, Xiuqing ;

Garcia, Melissa E. ;

Jensen, Rich ;

Keller, Margaux E. ;

Lettre, Guillaume ;

Lotay, Vaneet .

AMERICAN JOURNAL OF HUMAN GENETICS, 2013, 93 (03) :545-554

[9] The genetic architecture of type 2 diabetes [J].

Fuchsberger, Christian ;

Flannick, Jason ;

Teslovich, Tanya M. ;

Mahajan, Anubha ;

Agarwala, Vineeta ;

Gaulton, Kyle J. ;

Ma, Clement ;

Fontanillas, Pierre ;

Moutsianas, Loukas ;

McCarthy, Davis J. ;

Rivas, Manuel A. ;

Perry, John R. B. ;

Sim, Xueling ;

Blackwell, Thomas W. ;

Robertson, Neil R. ;

Rayner, N. William ;

Cingolani, Pablo ;

Locke, Adam E. ;

Tajes, Juan Fernandez ;

Highland, Heather M. ;

Dupuis, Josee ;

Chines, Peter S. ;

Lindgren, Cecilia M. ;

Hartl, Christopher ;

Jackson, Anne U. ;

Chen, Han ;

Huyghe, Jeroen R. ;

van de Bunt, Martijn ;

Pearson, Richard D. ;

Kumar, Ashish ;

Mueller-Nurasyid, Martina ;

Grarup, Niels ;

Stringham, Heather M. ;

Gamazon, Eric R. ;

Lee, Jaehoon ;

Chen, Yuhui ;

Scott, Robert A. ;

Below, Jennifer E. ;

Chen, Peng ;

Huang, Jinyan ;

Go, Min Jin ;

Stitzel, Michael L. ;

Pasko, Dorota ;

Parker, Stephen C. J. ;

Varga, Tibor V. ;

Green, Todd ;

Beer, Nicola L. ;

Day-Williams, Aaron G. ;

Ferreira, Teresa ;

Fingerlin, Tasha .

NATURE, 2016, 536 (7614) :41-+

[10] Effects of Long-Term Averaging of Quantitative Blood Pressure Traits on the Detection of Genetic Associations [J].

Ganesh, Santhi K. ;

Chasman, Daniel I. ;

Larson, Martin G. ;

Guo, Xiuqing ;

Verwoert, Germain ;

Bis, Joshua C. ;

Gu, Xiangjun ;

Smith, Albert V. ;

Yang, Min-Lee ;

Zhang, Yan ;

Ehret, Georg ;

Rose, Lynda M. ;

Hwang, Shih-Jen ;

Papanicolau, George J. ;

Sijbrands, Eric J. ;

Rice, Kenneth ;

Eiriksdottir, Gudny ;

Pihur, Vasyl ;

Ridker, Paul M. ;

Vasan, Ramachandran S. ;

Newton-Cheh, Christopher ;

Raffel, Leslie J. ;

Amin, Najaf ;

Rotter, Jerome I. ;

Liu, Kiang ;

Launer, Lenore J. ;

Xu, Ming ;

Caulfield, Mark ;

Morrison, Alanna C. ;

Johnson, Andrew D. ;

Vaidya, Dhananjay ;

Dehghan, Abbas ;

Li, Guo ;

Bouchard, Claude ;

Harris, Tamara B. ;

Zhang, He ;

Boerwinkle, Eric ;

Siscovick, David S. ;

Gao, Wei ;

Uitterlinden, Andre G. ;

Rivadeneira, Fernando ;

Hofman, Albert ;

Willer, Cristen J. ;

Franco, Oscar H. ;

Huo, Yong ;

Witteman, Jacqueline C. M. ;

Munroe, Patricia B. ;

Gudnason, Vilmundur ;

Palmas, Walter ;

van Duijn, Cornelia .

AMERICAN JOURNAL OF HUMAN GENETICS, 2014, 95 (01) :49-65

← 1 2 3 4 5 →

共 44 条

[1] The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans [J].

Ardlie, Kristin G. ;

DeLuca, David S. ;

Segre, Ayellet V. ;

Sullivan, Timothy J. ;

Young, Taylor R. ;

Gelfand, Ellen T. ;

Trowbridge, Casandra A. ;

Maller, Julian B. ;

Tukiainen, Taru ;

Lek, Monkol ;

Ward, Lucas D. ;

Kheradpour, Pouya ;

Iriarte, Benjamin ;

Meng, Yan ;

Palmer, Cameron D. ;

Esko, Tonu ;

Winckler, Wendy ;

Hirschhorn, Joel N. ;

Kellis, Manolis ;

MacArthur, Daniel G. ;

Getz, Gad ;

Shabalin, Andrey A. ;

Li, Gen ;

Zhou, Yi-Hui ;

Nobel, Andrew B. ;

Rusyn, Ivan ;

Wright, Fred A. ;

Lappalainen, Tuuli ;

Ferreira, Pedro G. ;

Ongen, Halit ;

Rivas, Manuel A. ;

Battle, Alexis ;

Mostafavi, Sara ;

Monlong, Jean ;

Sammeth, Michael ;

Mele, Marta ;

Reverter, Ferran ;

Goldmann, Jakob M. ;

Koller, Daphne ;

Guigo, Roderic ;

McCarthy, Mark I. ;

Dermitzakis, Emmanouil T. ;

Gamazon, Eric R. ;

Im, Hae Kyung ;

Konkashbaev, Anuar ;

Nicolae, Dan L. ;

Cox, Nancy J. ;

Flutre, Timothee ;

Wen, Xiaoquan ;

Stephens, Matthew .

SCIENCE, 2015, 348 (6235) :648-660

[2] Estimating her tability of complex traits from genonne-wide association studies using IBS-based Haseman-Elston regression [J].

Chen, Guo-Bo .

FRONTIERS IN GENETICS, 2014, 5

[3] Model-free Estimation of Recent Genetic Relatedness [J].

Conomos, Matthew P. ;

Reiner, Alexander P. ;

Weir, Bruce S. ;

Thornton, Timothy A. .

AMERICAN JOURNAL OF HUMAN GENETICS, 2016, 98 (01) :127-148

[4] Genomic control for association studies [J].

Devlin, B ;

Roeder, K .

BIOMETRICS, 1999, 55 (04) :997-1004

[5] The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals [J].

Ehret, Georg B. ;

Ferreira, Teresa ;

Chasman, Daniel I. ;

Jackson, Anne U. ;

Schmidt, Ellen M. ;

Johnson, Toby ;

Thorleifsson, Gudmar ;

Luan, Jian'an ;

Donnelly, Louise A. ;

Kanoni, Stavroula ;

Petersen, Ann -Kristin ;

Pihurl, Vasyl ;

Strawbridge, Rona J. ;

Shungin, Dmitry ;

Hughes, Maria F. ;

Meirelles, Osorio ;

Kaakinen, Marika ;

Bouatia-Naji, Nabila ;

Kristiansson, Kati ;

Shah, Sonia ;

Kleber, Marcus E. ;

Guo, Xiuqing ;

Lyytikainen, Leo-Pekka ;

Fava, Cristiano ;

Eriksson, Nidas ;

Nolte, Ilja M. ;

Magnusson, Patrik K. ;

Salfati, Elias L. ;

Rallidis, Loukianos S. ;

Theusch, Elizabeth ;

Smith, Andrew J. P. ;

Folkersen, Lasse ;

Witkowska, Kate ;

Pers, Tune H. ;

Joehanes, Roby ;

Kim, Stuart K. ;

Lataniotis, Lazaros ;

Jansen, Rick ;

Johnson, Andrew D. ;

Warren, Helen ;

Kim, Young Jin ;

Zhao, Wei ;

Wu, Ying ;

Tayo, Bamidele O. ;

Bochud, Murielle ;

Absher, Devin ;

Adair, Linda S. ;

Amin, Najaf ;

Arkingl, Dan E. ;

Axelsson, Tomas .

NATURE GENETICS, 2016, 48 (10) :1171-1184

[6] Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk [J].

Ehret, Georg B. ;

Munroe, Patricia B. ;

Rice, Kenneth M. ;

Bochud, Murielle ;

Johnson, Andrew D. ;

Chasman, Daniel I. ;

Smith, Albert V. ;

Tobin, Martin D. ;

Verwoert, Germaine C. ;

Hwang, Shih-Jen ;

Pihur, Vasyl ;

Vollenweider, Peter ;

O'Reilly, Paul F. ;

Amin, Najaf ;

Bragg-Gresham, Jennifer L. ;

Teumer, Alexander ;

Glazer, Nicole L. ;

Launer, Lenore ;

Zhao, Jing Hua ;

Aulchenko, Yurii ;

Heath, Simon ;

Sober, Siim ;

Parsa, Afshin ;

Luan, Jian'an ;

Arora, Pankaj ;

Dehghan, Abbas ;

Zhang, Feng ;

Lucas, Gavin ;

Hicks, Andrew A. ;

Jackson, Anne U. ;

Peden, John F. ;

Tanaka, Toshiko ;

Wild, Sarah H. ;

Rudan, Igor ;

Igl, Wilmar ;

Milaneschi, Yuri ;

Parker, Alex N. ;

Fava, Cristiano ;

Chambers, John C. ;

Fox, Ervin R. ;

Kumari, Meena ;

Go, Min Jin ;

van der Harst, Pim ;

Kao, Wen Hong Linda ;

Sjogren, Marketa ;

Vinay, D. G. ;

Alexander, Myriam ;

Tabara, Yasuharu ;

Shaw-Hawkins, Sue ;

Whincup, Peter H. .

NATURE, 2011, 478 (7367) :103-109

[7] Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study [J].

Fox, Ervin R. ;

Young, J. Hunter ;

Li, Yali ;

Dreisbach, Albert W. ;

Keating, Brendan J. ;

Musani, Solomon K. ;

Liu, Kiang ;

Morrison, Alanna C. ;

Ganesh, Santhi ;

Kutlar, Abdullah ;

Ramachandran, Vasan S. ;

Polak, Josef F. ;

Fabsitz, Richard R. ;

Dries, Daniel L. ;

Farlow, Deborah N. ;

Redline, Susan ;

Adeyemo, Adebowale ;

Hirschorn, Joel N. ;

Sun, Yan V. ;

Wyatt, Sharon B. ;

Penman, Alan D. ;

Palmas, Walter ;

Rotter, Jerome I. ;

Townsend, Raymond R. ;

Doumatey, Ayo P. ;

Tayo, Bamidele O. ;

Mosley, Thomas H., Jr. ;

Lyon, Helen N. ;

Kang, Sun J. ;

Rotimi, Charles N. ;

Cooper, Richard S. ;

Franceschini, Nora ;

Curb, J. David ;

Martin, Lisa W. ;

Eaton, Charles B. ;

Kardia, Sharon L. R. ;

Taylor, Herman A. ;

Caulfield, Mark J. ;

Ehret, Georg B. ;

Johnson, Toby ;

Chakravarti, Aravinda ;

Zhu, Xiaofeng ;

Levy, Daniel .

HUMAN MOLECULAR GENETICS, 2011, 20 (11) :2273-2284

[8] Genome-wide Association Analysis of Blood-Pressure Traits in African-Ancestry Individuals Reveals Common Associated Genes in African and Non-African Populations [J].

Franceschini, Nora ;

Fox, Ervin ;

Zhang, Zhaogong ;

Edwards, Todd L. ;

Nalls, Michael A. ;

Sung, Yun Ju ;

Tayo, Bamidele O. ;

Sun, Yan V. ;

Gottesman, Omri ;

Adeyemo, Adebawole ;

Johnson, Andrew D. ;

Young, J. Hunter ;

Rice, Ken ;

Duan, Qing ;

Chen, Fang ;

Li, Yun ;

Tang, Hua ;

Fornage, Myriam ;

Keene, Keith L. ;

Andrews, Jeanette S. ;

Smith, Jennifer A. ;

Fau, Jessica D. ;

Guangfa, Zhang ;

Guo, Wei ;

Liu, Yu ;

Murray, Sarah S. ;

Musani, Solomon K. ;

Srinivasan, Sathanur ;

Edwards, Digna R. Velez ;

Wang, Heming ;

Becker, Lewis C. ;

Bovet, Pascal ;

Bochud, Murielle ;

Broecke, Ulrich ;

Burnier, Michel ;

Carty, Cara ;

Chasman, Daniel I. ;

Ehret, Georg ;

Chen, Wei-Min ;

Chen, Guanjie ;

Chen, Wei ;

Ding, Jingzhong ;

Dreisbach, Albert W. ;

Evans, Michele K. ;

Guo, Xiuqing ;

Garcia, Melissa E. ;

Jensen, Rich ;

Keller, Margaux E. ;

Lettre, Guillaume ;

Lotay, Vaneet .

AMERICAN JOURNAL OF HUMAN GENETICS, 2013, 93 (03) :545-554

[9] The genetic architecture of type 2 diabetes [J].

Fuchsberger, Christian ;

Flannick, Jason ;

Teslovich, Tanya M. ;

Mahajan, Anubha ;

Agarwala, Vineeta ;

Gaulton, Kyle J. ;

Ma, Clement ;

Fontanillas, Pierre ;

Moutsianas, Loukas ;

McCarthy, Davis J. ;

Rivas, Manuel A. ;

Perry, John R. B. ;

Sim, Xueling ;

Blackwell, Thomas W. ;

Robertson, Neil R. ;

Rayner, N. William ;

Cingolani, Pablo ;

Locke, Adam E. ;

Tajes, Juan Fernandez ;

Highland, Heather M. ;

Dupuis, Josee ;

Chines, Peter S. ;

Lindgren, Cecilia M. ;

Hartl, Christopher ;

Jackson, Anne U. ;

Chen, Han ;

Huyghe, Jeroen R. ;

van de Bunt, Martijn ;

Pearson, Richard D. ;

Kumar, Ashish ;

Mueller-Nurasyid, Martina ;

Grarup, Niels ;

Stringham, Heather M. ;

Gamazon, Eric R. ;

Lee, Jaehoon ;

Chen, Yuhui ;

Scott, Robert A. ;

Below, Jennifer E. ;

Chen, Peng ;

Huang, Jinyan ;

Go, Min Jin ;

Stitzel, Michael L. ;

Pasko, Dorota ;

Parker, Stephen C. J. ;

Varga, Tibor V. ;

Green, Todd ;

Beer, Nicola L. ;

Day-Williams, Aaron G. ;

Ferreira, Teresa ;

Fingerlin, Tasha .

NATURE, 2016, 536 (7614) :41-+

[10] Effects of Long-Term Averaging of Quantitative Blood Pressure Traits on the Detection of Genetic Associations [J].

Ganesh, Santhi K. ;

Chasman, Daniel I. ;

Larson, Martin G. ;

Guo, Xiuqing ;

Verwoert, Germain ;

Bis, Joshua C. ;

Gu, Xiangjun ;

Smith, Albert V. ;

Yang, Min-Lee ;

Zhang, Yan ;

Ehret, Georg ;

Rose, Lynda M. ;

Hwang, Shih-Jen ;

Papanicolau, George J. ;

Sijbrands, Eric J. ;

Rice, Kenneth ;

Eiriksdottir, Gudny ;

Pihur, Vasyl ;

Ridker, Paul M. ;

Vasan, Ramachandran S. ;

Newton-Cheh, Christopher ;

Raffel, Leslie J. ;

Amin, Najaf ;

Rotter, Jerome I. ;

Liu, Kiang ;

Launer, Lenore J. ;

Xu, Ming ;

Caulfield, Mark ;

Morrison, Alanna C. ;

Johnson, Andrew D. ;

Vaidya, Dhananjay ;

Dehghan, Abbas ;

Li, Guo ;

Bouchard, Claude ;

Harris, Tamara B. ;

Zhang, He ;

Boerwinkle, Eric ;

Siscovick, David S. ;

Gao, Wei ;

Uitterlinden, Andre G. ;

Rivadeneira, Fernando ;

Hofman, Albert ;

Willer, Cristen J. ;

Franco, Oscar H. ;

Huo, Yong ;

Witteman, Jacqueline C. M. ;

Munroe, Patricia B. ;

Gudnason, Vilmundur ;

Palmas, Walter ;

van Duijn, Cornelia .

AMERICAN JOURNAL OF HUMAN GENETICS, 2014, 95 (01) :49-65

← 1 2 3 4 5 →