Prenylisoflavonoids from Erythrina senegalensis as Novel HIV-1 Protease Inhibitors

被引：32
|
作者：
Lee, JiSuk [1 ,2 ]
Oh, Won Keun [3 ]
Ahn, Jong Seog [3 ]
Kim, Yong Hae [4 ]
Mbafor, J. Tanyi [5 ]
Wandji, Jean [5 ]
Fomum, Z. Tanee [5 ]
机构：
[1] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea
[2] Seoul Natl Univ, Pharmaceut Sci Res Inst, Seoul 151742, South Korea
[3] KRIBB, Taejon, South Korea
[4] Korea Adv Inst Sci & Technol, Dept Chem, Taejon 305701, South Korea
[5] Univ Yaounde, Dept Organ Chem, Yaounde, Cameroon
来源：
PLANTA MEDICA | 2009年 / 75卷 / 03期
关键词：
Erythrina senegalensis; Leguminosae; prenylated isoflavonoids; HIV-1; protease; PRENYLATED FLAVONOIDS; STEM BARK; MOGHANIA-PHILIPPINENSIS; CONSTITUENTS; 8-PRENYLLUTEONE; ISOFLAVONOIDS; ROOTS; SEEDS;
D O I：
10.1055/s-0028-1088395
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Eight compounds were isolated from the CH2Cl2 extracts of Erythrina senegalensis to assess HIV-1 protease (PR) activity inhibition. The prenylated isoflavone structures, identified by spectroscopic analysis, were 8-prenylluteone (1), auriculatin (2), erysenegalensein O (3), erysenegalensein D (4), erysenegalensein N (5), derrone (6), alpinumisoflavone (7), and 6,8-diprenylgenistein (8). The constituents showed dose-dependent inhibitory activities on HIV-1 PR with IC50 values from 0.5 to 30.0 mu M. Compounds 1-5 possessing two hydroxy groups in the 2' and 4' positions of the B ring, potently inhibited HIV-1 PR activity. In addition, 6,8-diprenylgenistein (8) with two prenyl groups in the 6 and 8 positions of the A ring and one hydroxy group in the 4' position of B-ring was the most potent HIV-1 PR inhibitor.
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收藏
页码：268 / 270
页数：3
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