Observation of conserved solution-phase secondary structure in gas-phase tryptic peptides

被引：50
|
作者：
Ruotolo, BT
Verbeck, GF
Thomson, LM
Gillig, KJ
Russell, DH [1 ]
机构：
[1] Texas A&M Univ, Dept Chem, Lab Biol Mass Spectrometry, College Stn, TX 77843 USA
[2] Texas A&M Univ, Lab Mol Simulat, College Stn, TX 77843 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 16期
关键词：
D O I：
10.1021/ja0178113
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Results from ion mobility studies of tryptic peptides suggest that, in some cases, the gas-phase structures can be related to the solution-phase structure of the parent protein. The interpretation of ion mobility measurements is supported by results from molecular modeling and H/D exchange experiments on the same peptides. This study clearly illustrates the utility of IM-MS for screening complex mixtures for peptides having intrinsically stable secondary/tertiary structures, and/or posttranslational modification. Copyright © 2002 American Chemical Society.
引用
收藏
页码：4214 / 4215
页数：2
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