Prognostic impact of lung adenocarcinoma second predominant pattern from a large European database

被引:13
作者
Bertoglio, Pietro [1 ]
Querzoli, Giulia [2 ]
Ventura, Luigi [3 ]
Aprile, Vittorio [4 ]
Cattoni, Maria A. [5 ]
Nachira, Dania [6 ]
Lococo, Filippo [6 ]
Rodriguez Perez, Maria [7 ]
Guerrera, Francesco [8 ]
Minervini, Fabrizio [9 ]
Gnetti, Letizia [10 ]
Bacchin, Diana [4 ]
Franzi, Francesca [11 ]
Rindi, Guido [12 ]
Bellafiore, Salvatore [13 ]
Femia, Federico [8 ]
Viti, Andrea [1 ]
Bogina, Giuseppe S. [2 ]
Kestenholz, Peter [9 ]
Ruffini, Enrico [8 ]
Paci, Massimiliano [14 ]
Margaritora, Stefano [6 ]
Imperatori, Andrea S. [5 ]
Lucchi, Marco [4 ]
Ampollini, Luca [3 ]
Terzi, Alberto C. [1 ]
机构
[1] IRCCS Sacro Cuore Don Calabria Hosp, Div Thorac Surg, Via Sempreboni 5, I-37024 Verona, Italy
[2] IRCCS Sacro Cuore Don Calabria Hosp, Div Pathol Anat, Verona, Italy
[3] Univ Hosp Parma, Div Thorac Surg, Parma, Italy
[4] Univ Hosp Pisa, Div Thorac Surg, Pisa, Italy
[5] Univ Insubria, Div Thorac Surg, Varese, Italy
[6] Univ Cattolica Sacro Cuore, Fdn Policlin A Gemelli, Dept Gen Thorac Surg, Rome, Italy
[7] Clin Univ Navarra, Div Thorac Surg, Madrid, Spain
[8] Univ Torino, Div Thorac Surg, Turin, Italy
[9] Cantonal Hosp Lucerne, Div Thorac Surg, Luzern, Switzerland
[10] Univ Hosp Parma, Div Pathol Anat, Parma, Italy
[11] Univ Insubria, Div Pathol Anat, Varese, Italy
[12] Univ Cattolica Sacro Cuore, Fdn Policlin A Gemelli, Div Pathol Anat, Rome, Italy
[13] Azienda USL Reggio Emilia IRCCS, Div Pathol Anat, Reggio Emilia, Italy
[14] Azienda USL Reggio Emilia IRCCS, Div Thorac Surg, Reggio Emilia, Italy
关键词
lung adenocarcinoma; lung cancer biology; lung cancer surgery; non‐ small‐ cell lung cancer; RESPIRATORY SOCIETY CLASSIFICATION; INTERNATIONAL ASSOCIATION; HISTOLOGIC SUBTYPE; MICROPAPILLARY; RECURRENCE; SYSTEM; TUMORS;
D O I
10.1002/jso.26292
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background and Objectives Adenocarcinoma patterns could be grouped based on clinical behaviors: low- (lepidic), intermediate- (papillary or acinar), and high-grade (micropapillary and solid). We analyzed the impact of the second predominant pattern (SPP) on disease-free survival (DFS). Methods We retrospectively collected data of surgically resected stage I and II adenocarcinoma. Selection criteria: anatomical resection with lymphadenectomy and pathological N0. Pure adenocarcinomas and mucinous subtypes were excluded. Recurrence rate and factors affecting DFS were analyzed according to the SPP focusing on intermediate-grade predominant pattern adenocarcinomas. Results Among 270 patients, 55% were male. The mean age was 68.3 years. SPP pattern appeared as follows: lepidic 43.0%, papillary 23.0%, solid 14.4%, acinar 11.9%, and micropapillary 7.8%. The recurrence rate was 21.5% and 5-year DFS was 71.1%. No difference in DFS was found according to SPP (p = .522). In patients with high-grade SPP, the percentage of SPP, age, and tumor size significantly influenced DFS (p = .016). In patients with lepidic SPP, size, male gender, and lymph-node sampling (p = .005; p = .014; p = .038, respectively) significantly influenced DFS. Conclusions The impact of SPP on DFS is not homogeneous in a subset of patients with the intermediate-grade predominant patterns. The influence of high-grade SPP on DFS is related to its proportion in the tumor.
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收藏
页码:560 / 569
页数:10
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