Hemagglutination Inhibition Antibody Response Following Influenza A(H1N1)pdm09 Virus Natural Infection: A Cross-Sectional Study from Thirthahalli, Karnataka, India

被引：2

作者：

Alladi, Chandana Sai Hari ^{[1
]}

Jagadesh, Anitha ^{[1
]}

Prabhu, Suresha G. ^{[1
]}

Arunkumar, Govindakarnavar ^{[1
]}

机构：

[1] Manipal Acad Higher Educ, Manipal Ctr Virus Res, Manipal 576104, Karnataka, India

来源：

VIRAL IMMUNOLOGY | 2019年 / 32卷 / 05期

关键词：

influenza virus; hemagglutination-inhibition assay; immune response; pre-existing antibodies; IMMUNE-RESPONSES; VACCINE;

D O I：

10.1089/vim.2019.0010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Influenza viruses are major respiratory pathogens that cause seasonal epidemics and occasional pandemics. Immune response to influenza viruses is majorly targeted against the hemagglutinin antigen. A laboratory-based retrospective cross-sectional study was conducted on 50 acute and 50 follow-up samples to assess the immune response to influenza A(H1N1)pdm09 virus after natural infection and detect the presence of pre-existing antibodies against influenza A(H3N2) and influenza B viruses. Two-fourfold rise in hemagglutination-inhibition (HAI) titer was observed in 100% of the follow-up samples for influenza A(H1N1)pdm09 virus. No change in HAI titers for influenza A(H3N2) and influenza B viruses was observed.

引用

页码：230 / 233

页数：4

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