Determinants of uterine aging: lessons from rodent models

被引：23
作者：
Kong ShuangBo [1 ,2 ]
Zhang Shuang [1 ,2 ]
Chen YongJie [1 ,2 ]
Wang WeiXiang [1 ]
Wang BingYan [1 ]
Chen Qi [1 ]
Duan EnKui [1 ]
Wang HaiBin [1 ]
机构：
[1] Chinese Acad Sci, State Key Lab Reprod Biol, Inst Zool, Beijing 100101, Peoples R China
[2] Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China
来源：
SCIENCE CHINA-LIFE SCIENCES | 2012年 / 55卷 / 08期
基金：
中国国家自然科学基金;
关键词：
determinants; uterine aging; rodent models; TERM REPRODUCTIVE PERFORMANCE; STROMAL CELL DECIDUALIZATION; SENESCENT GOLDEN-HAMSTERS; AGE-RELATED DECLINE; FEMALE RATS; MATERNAL AGE; DELAYED CHILDBEARING; MOUSE UTERUS; LITTER-SIZE; EMBRYO IMPLANTATION;
D O I：
10.1007/s11427-012-4356-1
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The uterus is an indispensable organ for the development of a new life in eutherian mammals. The female mammalian reproductive capacity diminishes with age. In this respect, the senescence of uterine endometrium is convinced to contribute to this failure. This review focuses on the physiological function of the uterus and the related influence of aging mainly in rodent models. A better understanding of the underlying mechanisms governing the process of uterine aging is hoped to generate new strategies to prolong the reproductive lifespan in humans.
引用
收藏
页码：687 / 693
页数：7
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