The Need for Translational Research on Drug-Drug Interactions

被引：21

作者：

Hennessy, S. ^{[1
,2
]}

Flockhart, D. A. ^{[3
,4
]}

机构：

[1] Univ Penn, Dept Pharmacol, Ctr Clin Epidemiol, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA

[2] Univ Penn, Inst Translat Med & Therapeut, Philadelphia, PA 19104 USA

[3] Indiana Univ Sch Med, Indiana Inst Personalized Med, Indianapolis, IN USA

[4] Indiana Univ Sch Med, Div Clin Pharmacol, Indianapolis, IN USA

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2012年 / 91卷 / 05期

关键词：

D O I：

10.1038/clpt.2012.39

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Drug-drug interactions (DDIs) are an important clinical and public health concern. Although DDI screening now occurs during drug development, it is difficult to predict clinical importance based on in vitro experiments. Furthermore, older drugs that were not screened may have interactions that have not yet been identified. In this Commentary, we review the importance of DDIs and argue that a translational research approach is needed to produce clinically actionable information as well as generalizable biological knowledge.

引用

页码：771 / 773

页数：4

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