Prognostic Value of Dual-Time-Point 18F-FDG PET for Idiopathic Pulmonary Fibrosis

被引：40

作者：

Umeda, Yukihiro ^{[1
]}

Demura, Yoshiki ^{[2
]}

Morikawa, Miwa ^{[1
]}

Anzai, Masaki ^{[1
]}

Kadowaki, Maiko ^{[1
]}

Ameshima, Shingo ^{[1
]}

Tsuchida, Tatsuro ^{[3
]}

Tsujikawa, Tetsuya ^{[4
]}

Kiyono, Yasushi ^{[4
]}

Okazawa, Hidehiko ^{[4
]}

Ishizaki, Takeshi ^{[5
]}

Ishizuka, Tamotsu ^{[1
]}

机构：

[1] Univ Fukui, Dept Internal Med 3, Eiheiji, Fukui 9101193, Japan

[2] Fukui Red Cross Hosp, Dept Resp Med, Fukui, Fukui, Japan

[3] Univ Fukui, Fac Med Sci, Dept Radiol, Eiheiji, Fukui 9101193, Japan

[4] Univ Fukui, Fac Med Sci, Biomed Imaging Res Ctr, Eiheiji, Fukui 9101193, Japan

[5] Resp Dis Ctr, Northern Noto Area, Anamizu, Ishikawa, Japan

来源：

JOURNAL OF NUCLEAR MEDICINE | 2015年 / 56卷 / 12期

关键词：

fluorodeoxyglucose F-18; idiopathic pulmonary fibrosis; positron emission tomography; survival analysis; POSITRON-EMISSION-TOMOGRAPHY; LUNG-DISEASE; HEXOKINASE TRANSLOCATION; DIAGNOSIS; TRIAL; DIFFERENTIATION; TRANSPLANTATION; INFLAMMATION; PIRFENIDONE; SURVIVAL;

D O I：

10.2967/jnumed.115.163360

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The aim of this prospective study was to clarify whether dual-timepoint F-18-FDG PET imaging results are useful to predict long-term survival of idiopathic pulmonary fibrosis (IPF) patients. Methods: Fifty IPF patients underwent F-18-FDG PET examinations at 2 time points: 60 min (early imaging) and 180 min (delayed imaging) after F-18-FDG injection. The standardized uptake value (SUV) at each point and retention index value (RI-SUV) calculated from those were evaluated, and then the results were compared with overall and progressionfree survival. Results: A multivariate Cox proportional hazards model showed higher RI-SUV and higher extent of fibrosis score as independent predictors of shorter progression-free survival. The median progression-free survival for patients with negative RI-SUV was better than that for those with positive RI-SUV (27.9 vs. 13.3 mo, P = 0.0002). On the other hand, multivariate Cox analysis showed higher RI-SUV and lower forced vital capacity to be independent predictors of shorter overall survival. The 5-y survival rate for patients with negative RI-SUV was better than that for those with positive RI-SUV (76.8% vs. 14.3%, P = 0.00001). In addition, a univariate Cox model showed that positive RI-SUV as a binary variable was a significant indicator of mortality (hazard ratio, 7.31; 95% confidence interval, 2.64-20.3; P = 0.0001). Conclusion: Our results demonstrate that positive RI-SUV is strongly predictive of earlier deterioration of pulmonary function and higher mortality in patients with IPF.

引用

页码：1869 / 1875

页数：7

共 31 条

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