Healthy lifestyle and diet are associated with significant reduction in risk of obesity, type 2 diabetes, and cardiovascular diseases. Oxidative stress and the imbalance between prooxidants and antioxidants are linked to cardiovascular and metabolic diseases. Changes in antioxidant capacity of the body may lead to oxidative stress and vascular dysfunction. Diet is an important source of antioxidants, while exercise offers many health benefits as well. Recent findings have evidenced that diet and physical factors are correlated to oxidative stress. Diet and physical factors have debatable roles in modulating oxidative stress and effects on the endothelium. Since endothelium and oxidative stress play critical roles in cardiovascular and metabolic diseases, dietary and physical factors could have significant implications on prevention of the diseases. This review is aimed at summarizing the current knowledge on the impact of diet manipulation and physical factors on endothelium and oxidative stress, focusing on cardiovascular and metabolic diseases. We discuss the friend-and-foe role of dietary modification (including different diet styles, calorie restriction, and nutrient supplementation) on endothelium and oxidative stress, as well as the potential benefits and concerns of physical activity and exercise on endothelium and oxidative stress. A fine balance between oxidative stress and antioxidants is important for normal functions in the cells and interfering with this balance may lead to unfavorable effects. Further studies are needed to identify the best diet composition and exercise intensity.
机构:Univ Calif Davis, USDA, ARS, Western Human Nutr Res Ctr, Davis, CA 95616 USA
Adkins, Yuriko
Kelley, Darshan S.
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Univ Calif Davis, USDA, ARS, Western Human Nutr Res Ctr, Davis, CA 95616 USAUniv Calif Davis, USDA, ARS, Western Human Nutr Res Ctr, Davis, CA 95616 USA
机构:
Manchester Metropolitan Univ, Dept Biol Sci, Biomed Sci Res Grp, Manchester M1 5GD, Lancs, EnglandManchester Metropolitan Univ, Dept Biol Sci, Biomed Sci Res Grp, Manchester M1 5GD, Lancs, England
机构:
McMaster Univ, Dept Med, Hamilton, ON, Canada
Hamilton Hlth Sci, Populat Hlth Res Inst, Hamilton, ON, Canada
McMaster Univ, Hamilton, ON, CanadaMcMaster Univ, Dept Med, Hamilton, ON, Canada
Anand, Sonia S.
Hawkes, Corinna
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City Univ London, Ctr Food Policy, London EC1V 0HB, EnglandMcMaster Univ, Dept Med, Hamilton, ON, Canada
Hawkes, Corinna
de Souza, Russell J.
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McMaster Univ, Dept Clin Epidemiol & Biostat, Hamilton, ON, CanadaMcMaster Univ, Dept Med, Hamilton, ON, Canada
de Souza, Russell J.
Mente, Andrew
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h-index: 0
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Hamilton Hlth Sci, Populat Hlth Res Inst, Hamilton, ON, Canada
McMaster Univ, Hamilton, ON, CanadaMcMaster Univ, Dept Med, Hamilton, ON, Canada
Mente, Andrew
Dehghan, Mahshid
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h-index: 0
机构:
Hamilton Hlth Sci, Populat Hlth Res Inst, Hamilton, ON, Canada
McMaster Univ, Hamilton, ON, CanadaMcMaster Univ, Dept Med, Hamilton, ON, Canada
Dehghan, Mahshid
Nugent, Rachel
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h-index: 0
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Univ Washington, Dept Global Hlth, Seattle, WA 98195 USAMcMaster Univ, Dept Med, Hamilton, ON, Canada
Nugent, Rachel
Zulyniak, Michael A.
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McMaster Univ, Dept Med, Hamilton, ON, CanadaMcMaster Univ, Dept Med, Hamilton, ON, Canada
Zulyniak, Michael A.
Weis, Tony
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机构:
Univ Western Ontario, Dept Geog, London, ON N6A 5C2, CanadaMcMaster Univ, Dept Med, Hamilton, ON, Canada
机构:Univ Calif Davis, USDA, ARS, Western Human Nutr Res Ctr, Davis, CA 95616 USA
Adkins, Yuriko
Kelley, Darshan S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Davis, USDA, ARS, Western Human Nutr Res Ctr, Davis, CA 95616 USAUniv Calif Davis, USDA, ARS, Western Human Nutr Res Ctr, Davis, CA 95616 USA
机构:
Manchester Metropolitan Univ, Dept Biol Sci, Biomed Sci Res Grp, Manchester M1 5GD, Lancs, EnglandManchester Metropolitan Univ, Dept Biol Sci, Biomed Sci Res Grp, Manchester M1 5GD, Lancs, England
机构:
McMaster Univ, Dept Med, Hamilton, ON, Canada
Hamilton Hlth Sci, Populat Hlth Res Inst, Hamilton, ON, Canada
McMaster Univ, Hamilton, ON, CanadaMcMaster Univ, Dept Med, Hamilton, ON, Canada
Anand, Sonia S.
Hawkes, Corinna
论文数: 0引用数: 0
h-index: 0
机构:
City Univ London, Ctr Food Policy, London EC1V 0HB, EnglandMcMaster Univ, Dept Med, Hamilton, ON, Canada
Hawkes, Corinna
de Souza, Russell J.
论文数: 0引用数: 0
h-index: 0
机构:
McMaster Univ, Dept Clin Epidemiol & Biostat, Hamilton, ON, CanadaMcMaster Univ, Dept Med, Hamilton, ON, Canada
de Souza, Russell J.
Mente, Andrew
论文数: 0引用数: 0
h-index: 0
机构:
Hamilton Hlth Sci, Populat Hlth Res Inst, Hamilton, ON, Canada
McMaster Univ, Hamilton, ON, CanadaMcMaster Univ, Dept Med, Hamilton, ON, Canada
Mente, Andrew
Dehghan, Mahshid
论文数: 0引用数: 0
h-index: 0
机构:
Hamilton Hlth Sci, Populat Hlth Res Inst, Hamilton, ON, Canada
McMaster Univ, Hamilton, ON, CanadaMcMaster Univ, Dept Med, Hamilton, ON, Canada
Dehghan, Mahshid
Nugent, Rachel
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Global Hlth, Seattle, WA 98195 USAMcMaster Univ, Dept Med, Hamilton, ON, Canada
Nugent, Rachel
Zulyniak, Michael A.
论文数: 0引用数: 0
h-index: 0
机构:
McMaster Univ, Dept Med, Hamilton, ON, CanadaMcMaster Univ, Dept Med, Hamilton, ON, Canada
Zulyniak, Michael A.
Weis, Tony
论文数: 0引用数: 0
h-index: 0
机构:
Univ Western Ontario, Dept Geog, London, ON N6A 5C2, CanadaMcMaster Univ, Dept Med, Hamilton, ON, Canada