Immunological markers that predict radiation toxicity

被引：53
作者：
Sprung, Carl N. [1 ,2 ]
Forrester, Helen B. [1 ,2 ]
Siva, Shankar [3 ,4 ]
Martin, Olga A. [3 ,4 ,5 ]
机构：
[1] MIMR PHI Inst Med Res, Ctr Innate Immunol & Infect Dis, Clayton, Vic 3168, Australia
[2] Monash Univ, Dept Mol & Translat Sci, Clayton, Vic, Australia
[3] Peter MacCallum Canc Ctr, Div Radiat Oncol & Canc Imaging, Melbourne, Vic, Australia
[4] Univ Melbourne, Sir Peter MacCallum Dept Oncol, Melbourne, Vic, Australia
[5] Peter MacCallum Canc Ctr, Mol Radiat Biol Lab, Melbourne, Vic, Australia
来源：
CANCER LETTERS | 2015年 / 368卷 / 02期
基金：
英国医学研究理事会; 美国国家卫生研究院;
关键词：
Radiation sensitivity; Immunology; Biomarker; Radiotherapy; Inflammation; GROWTH-FACTOR-BETA; INDUCED PULMONARY-FIBROSIS; GENE-EXPRESSION PROFILE; NORMAL TISSUE-REACTIONS; NF-KAPPA-B; CANCER-PATIENTS; LUNG-CANCER; RADIOTHERAPY; DAMAGE; CELLS;
D O I：
10.1016/j.canlet.2015.01.045
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Radiotherapy is a major modality of cancer treatment responsible for a large proportion of cancer that is cured. Radiation exposure induces an inflammatory response which can be influenced by genetic, epigenetic, tumour, health and other factors which can lead to very different treatment outcomes between individuals. Molecules involved in the immunological response provide excellent potential biomarkers for the prediction of radiation-induced toxicity. The known molecular and cellular immunological responses in relation to radiation and the potential to improve cancer treatment are presented in this review. In particular, immunological biomarkers of radiation-induced fibrosis and pneumonitis in cancer radiotherapy patients are discussed. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：191 / 197
页数：7
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