A red-emitting water-soluble fluorescent probe for biothiol detection with a large Stokes shift

被引：46
|
作者：
Yang, Lei [1 ]
Xiong, Haiqing [1 ]
Su, Yuanan [1 ]
Tian, Huihui [1 ]
Liu, Xingjiang [3 ]
Song, Xiangzhi [1 ,2 ]
机构：
[1] Cent S Univ, Coll Chem & Chem Engn, Changsha 410083, Hunan, Peoples R China
[2] Key Lab Hunan Prov Water Environm & Agr Prod Safe, Changsha 410083, Hunan, Peoples R China
[3] Zhengzhou Univ, Coll Chem & Mol Engn, Zhengzhou 450001, Henan, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2019年 / 30卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Fluorescent probe; Biothiol; Water-soluble; Red-emitting; Large Stokes shift; GLUTATHIONE; THIOLS; HOMOCYSTEINE; CYSTEINE;
D O I：
10.1016/j.cclet.2018.12.017
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In this work, we presented a fluorescent probe (MCQ-DNBS) for selective and sensitive detection of biothiols based on a methylated chromenoquinoline (MCQ) derivative. Probe MCQ-DNBS was constructed by masking the OH group in MCQ with a common sensing unit, 2,4-dinitrobezensulfonate group (DNBS) for biothiols. Due to the photo-induced electron transfer (PET) process between MCQ and DNBS, this probe was weekly fluorescent. Upon the addition of biothiols (Cys, Hcy and GSH), this probe emitted a strong red fluorescence (lambda(em max)= 613 nm) with a large Stokes shift (115 nm). In addition, fluorescence imaging of biothiols in living cells was successfully realized using MCQ-DNBS as a detector. (C) 2018 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：563 / 565
页数：3
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