New Sustainable Process for Hesperidin Isolation and Anti-Ageing Effects of Hesperidin Nanocrystals

被引：49

作者：

Stanisic, Danijela ^{[1
]}

Liu, Leticia H. B. ^{[1
]}

dos Santos, Roney V. ^{[1
]}

Costa, Amanda F. ^{[1
]}

Duran, Nelson ^{[2
,3
]}

Tasic, Ljubica ^{[1
]}

机构：

[1] Univ Campinas UNICAMP, Biol Chem Lab, Dept Organ Chem, Inst Chem, BR-13083970 Campinas, SP, Brazil

[2] Univ Estadual Campinas, Dept Struct & Funct Biol, Lab Urogenital Carcinogenesis & Immunotherapy, BR-13083862 Campinas, SP, Brazil

[3] Fed Univ ABC UFABC, Nanomed Res Unit Nanomed, BR-09210580 Santo Andre, SP, Brazil

来源：

MOLECULES | 2020年 / 25卷 / 19期

关键词：

hesperidin; new-clean process extraction; nanocrystals; antioxidant; anti-ageing; IN-VIVO; ANTIINFLAMMATORY PROPERTIES; FLAVANONES HESPERIDIN; FLAVONOIDS; ANTIOXIDANT; CHEMOPREVENTION; CARCINOGENESIS; PENETRATION; INHIBITION; QUERCETIN;

D O I：

10.3390/molecules25194534

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hesperidin, a secondary orange (Citrus sinensis) metabolite, was extracted from orange bagasse. No organic solvents or additional energy consumption were used in the clean and sustainable process. Hesperidin purity was approximately 98% and had a yield of 1%. Hesperidin is a known supplement due to antioxidant, chelating, and anti-ageing properties. Herein, hesperidin application to eliminate dark eye circles, which are sensitive and thin skin regions, was studied. In addition, the proposed method for its aqueous extraction was especially important for human consumption. Further, the most effective methods for hesperidin nanonization were explored, after which the nanoemulsions were incorporated into a cream formulation that was formulated for a tropical climate. Silky cream formulations (oil in water) were tested in vitro on artificial 3D skin from cultured cells extracted from skin residues after plastic surgery. The proposed in vitro assay avoided tests of the different formulations in human volunteers and animals. It was shown that one of the nanonized hesperidin formulations was the most skin-friendly and might be used in cosmetics.

引用

页数：18