Aldehydes and Ketones Formation: Copper-Catalyzed Aerobic Oxidative Decarboxylation of Phenylacetic Acids and α-Hydroxyphenylacetic Acids

被引：105
作者：
Feng, Qiang [1 ]
Song, Qiuling [1 ]
机构：
[1] Huaqiao Univ, Coll Chem Engn, Inst Next Generat Matter Transformat, Xiamen 361021, Fujian, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 79卷 / 04期
基金：
美国国家科学基金会;
关键词：
HETEROAROMATIC CARBOXYLIC-ACIDS; CROSS-COUPLING REACTION; ARYL HALIDES; BOND-CLEAVAGE; ALCOHOLS; PD; NANOPARTICLES; OLEFINATION;
D O I：
10.1021/jo402778p
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Aromatic aldehydes or ketones from copper catalyzed aerobic oxidative decarboxylation of phenylacetic acids and alpha-hydroxyphenylacetic acids have been synthesized. This reaction combined decarboxylation, dioxygen activation, and C-H bond oxidation steps in a one-pot protocol with molecular oxygen as the sole terminal oxidant. This reaction represents a novel decarboxylation of an sp(3)-hybridized carbon and the use of a benzylic carboxylic acid as a source of carbonyl compounds.
引用
收藏
页码：1867 / 1871
页数：5
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