Defining prostate cancer risk before prostate biopsy

被引：21
|
作者：
Pal, Raj P. [1 ]
Maitra, Neil U. [1 ]
Mellon, J. Kilian [1 ]
Khan, Masood A. [1 ]
机构：
[1] Univ Hosp Leicester NHS Trust, Leicester Gen Hosp, Dept Urol, Leicester LE5 4PW, Leics, England
来源：
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS | 2013年 / 31卷 / 08期
关键词：
Prostate cancer; Biopsy; Urine; Serum; Imaging; DIGITAL RECTAL EXAMINATION; MOLECULAR URINE ASSAY; COENZYME-A RACEMASE; TMPRSS2-ERG FUSION TRANSCRIPTS; ACID-PHOSPHATASE-ACTIVITY; METHYLACYL-COA RACEMASE; GLANDULAR KALLIKREIN 2; LONG-TERM PREDICTION; RADICAL PROSTATECTOMY; ANTIGEN PSA;
D O I：
10.1016/j.urolonc.2012.05.012
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Prostate cancer is the most commonly diagnosed cancer in men. At present, patients are selected for prostate biopsy on the basis of age, serum prostate specific antigen (PSA), and prostatic digital rectal examination (DRE) findings. However, due to limitations in the use of PSA and DRE, many patients undergo unnecessary prostate biopsy. A further problem arises as many patients are diagnosed and treated for indolent disease. This review of the literature highlights the strengths and weaknesses of existing methods of prebiopsy risk stratification and evaluates promising serum, urine, and radiologic prostate cancer biomarkers, which may improve risk stratification for prostate biopsy in the future. (C) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码：1408 / 1418
页数：11
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