Mononuclear copper active-oxygen complexes

被引：178

作者：

Itoh, S ^{[1
]}

机构：

[1] Osaka City Univ, Grad Sch Sci, Dept Chem, Sumiyoshi Ku, Osaka 5588585, Japan

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2006年 / 10卷 / 02期

关键词：

D O I：

10.1016/j.cbpa.2006.02.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

There have been significant advances in the understanding of the dioxygen-activation chemistry of mononuclear copper monooxygenases such as pepticlylglycine alpha-amidating monooxygenase and dopamine beta-monooxygenase (D beta M). Recent structural and spectroscopic studies on a series of biomimetic model compounds have provided new and valuable insights into the key reactive intermediates involved in the dioxygen processing at the mononuclear copper reaction centers in biological systems.

引用

页码：115 / 122

页数：8

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