Case report: Eosinophilic fasciitis induced by pembrolizumab with high FDG uptake on 18F-FDG-PET/CT

被引：7
作者：
Amrane, Karim [1 ,2 ]
Le Meur, Coline [1 ]
Thuillier, Philippe [3 ,4 ]
Alemany, Pierre [5 ]
Niel, Clemence [6 ]
Renault, David [6 ]
Abgral, Ronan [4 ,7 ]
机构：
[1] Ctr Hosp Pays Morlaix, Dept Oncol, Morlaix, France
[2] Univ Brest, Inst Natl Sante & Rech Med UMR 1227, INSERM, Lymphocytes B & Autoimmunite,LabEx IGO, Brest, France
[3] Univ Western Brittany, Inst Natl Sante & Rech Med UMR GETBO 1304, Brest, France
[4] Univ Hosp Brest, Dept Endocrinol, Brest, France
[5] Ouest Pathol, Dept Pathol, Brest, France
[6] Ctr Hosp Pays Morlaix, Dept Pneumol, Morlaix, France
[7] Univ Hosp Brest, Dept Nucl Med, Brest, France
来源：
FRONTIERS IN MEDICINE | 2022年 / 9卷
关键词：
NSCLC; eosinophilic fasciitis; F-18-FDG-PET; CT; pembrolizumab; ICI; DIAGNOSIS; MRI;
D O I：
10.3389/fmed.2022.1078560
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Eosinophilic fasciitis (EF) is a rare connective tissue disorder causing inflammation and fibrosing of fascia. In this study, we present a very rare case of an immune checkpoint inhibitor (ICI)-induced EF revealed by F-18-fluorodesoxyglucose positron emission tomography (FDG-PET/CT) 20 months after the initiation of Pembrolizumab treatment of a relapsed non-small cell lung cancer (NSCLC). This study presents a 52-year-old Caucasian woman clinically presenting asthenia, inflammatory muscle, and joint pain associated with subcutaneous nodules and symmetrical edema of the lower limbs. Iterative (18)FDG-PET/CT scans allow us to guide the therapeutic strategy due to this atypical ICI adverse event.
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相关论文
共 13 条
[1]   Rational use of 18F-FDG PET/CT in patients with advanced cutaneous melanoma: A systematic review [J].
Bisschop, C. ;
de Heer, E. C. ;
Brouwers, A. H. ;
Hospers, G. A. P. ;
Jalving, M. .
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2020, 153
[2]   Radiologic Manifestations of Immune-Related Adverse Events in Patients With Metastatic Melanoma Undergoing Anti-CTLA-4 Antibody Therapy [J].
Bronstein, Yulia ;
Ng, Chaan S. ;
Hwu, Patrick ;
Hwu, Wen-Jen .
AMERICAN JOURNAL OF ROENTGENOLOGY, 2011, 197 (06) :W992-W1000
[3]   Eosinophilic Fasciitis Following Checkpoint Inhibitor Therapy: Four Cases and a Review of Literature [J].
Chan, Karmela Kim ;
Magro, Cynthia ;
Shoushtari, Alexander ;
Rudin, Charles ;
Rotemberg, Veronica ;
Rossi, Anthony ;
Lezcano, Cecilia ;
Carrino, John ;
Fernandez, David ;
Postow, Michael A. ;
Apollo, Arlyn ;
Lacouture, Mario E. ;
Bass, Anne R. .
ONCOLOGIST, 2020, 25 (02) :140-149
[4]   Positron emission tomography in the diagnosis of eosinophilic fasciitis [J].
Cheriet, S. ;
Chastan, M. ;
Levesque, H. ;
Marie, I. .
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, 2011, 104 (11) :987-988
[5]   From diagnosis to remission: place of MRI in eosinophilic fasciitis [J].
Desvignes-Engelbert, Alexandra ;
Sauliere, Norbert ;
Loeuille, Damien ;
Blum, Alain ;
Chary-Valckenaere, Isabelle .
CLINICAL RHEUMATOLOGY, 2010, 29 (12) :1461-1464
[6]   Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial [J].
Herbst, Roy S. ;
Baas, Paul ;
Kim, Dong-Wan ;
Felip, Enriqueta ;
Perez-Gracia, Jose L. ;
Han, Ji-Youn ;
Molina, Julian ;
Kim, Joo-Hang ;
Arvis, Catherine Dubos ;
Ahn, Myung-Ju ;
Majem, Margarita ;
Fidler, Mary J. ;
de Castro, Gilberto, Jr. ;
Garrido, Marcelo ;
Lubiniecki, Gregory M. ;
Shentu, Yue ;
Im, Ellie ;
Dolled-Filhart, Marisa ;
Garon, Edward B. .
LANCET, 2016, 387 (10027) :1540-1550
[7]   Eosinophilic Fasciitis and Acute Encephalopathy Toxicity from Pembrolizumab Treatment of a Patient with Metastatic Melanoma [J].
Khoja, Leila ;
Maurice, Catherine ;
Chappell, MaryAnne ;
MacMillan, Leslie ;
Al-Habeeb, Ayman S. ;
Al-Faraidy, Nada ;
Butler, Marcus O. ;
Rogalla, Patrik ;
Mason, Warren ;
Joshua, Anthony M. ;
Hogg, David .
CANCER IMMUNOLOGY RESEARCH, 2016, 4 (03) :175-178
[8]   Usefulness of FDG PET/CT in the Diagnosis of Eosinophilic Fasciitis [J].
Kim, Hyun Jeong ;
Lee, Sang-Won ;
Kim, Gi Jeong ;
Lee, Jae-Hoon .
CLINICAL NUCLEAR MEDICINE, 2014, 39 (09) :801-802
[9]   Severe eosinophilic fasciitis: comparison of treatment with D-penicillamine plus corticosteroids vs. corticosteroids alone [J].
Mendoza, F. A. ;
Bai, R. ;
Kebede, A. G. ;
Jimenez, S. A. .
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, 2016, 45 (02) :129-134
[10]   Eosinophilic fasciitis: Spectrum of MRI findings [J].
Moulton, SJ ;
Kransdorf, MJ ;
Ginsburg, WW ;
Abril, A ;
Persellin, S .
AMERICAN JOURNAL OF ROENTGENOLOGY, 2005, 184 (03) :975-978
12