Alcohol consumption and risk of type 2 diabetes in European men and women: influence of beverage type and body size The EPIC-InterAct study

被引：61

作者：

Beulens, J. W. J. ^{[1
]}

van der Schouw, Y. T. ^{[1
]}

Bergmann, M. M. ^{[2
]}

Rohrmann, S. ^{[3
]}

Schulze, M. B. ^{[2
]}

Buijsse, B. ^{[2
]}

Grobbee, D. E. ^{[1
]}

Arriola, L. ^{[4
]}

Cauchi, S. ^{[5
]}

Tormo, M-J ^{[6
,7
]}

Allen, N. E. ^{[8
]}

van der A, D. L. ^{[9
]}

Balkau, B. ^{[10
]}

Boeing, H. ^{[2
]}

Clavel-Chapelon, F. ^{[10
]}

de Lauzon-Guillan, B. ^{[10
]}

Franks, P. ^{[11
]}

Froguel, P. ^{[12
]}

Gonzales, C. ^{[13
]}

Halkjaer, J. ^{[14
]}

Huerta, J. M. ^{[6
,7
]}

Kaaks, R. ^{[3
]}

Key, T. J. ^{[8
]}

Khaw, K. T. ^{[15
]}

Krogh, V. ^{[16
]}

Molina-Montes, E. ^{[17
]}

Nilsson, P. ^{[11
]}

Overvad, K. ^{[18
]}

Palli, D. ^{[19
]}

Panico, S. ^{[20
]}

Ramon Quiros, J. ^{[21
]}

Ronaldsson, O. ^{[22
]}

Romieu, I. ^{[23
]}

Romaguera, D. ^{[12
]}

Sacerdote, C. ^{[24
]}

Sanchez, M-J ^{[17
]}

Spijkerman, A. M. W. ^{[9
]}

Teucher, B. ^{[3
]}

Tjonneland, A. ^{[14
]}

Tumino, R. ^{[25
]}

Sharp, S. ^{[26
]}

Forouhi, N. G. ^{[26
]}

Langenberg, C. ^{[26
]}

Feskens, E. J. M. ^{[27
]}

Riboli, E. ^{[12
]}

Wareham, N. J. ^{[26
]}

机构：

[1] Univ Med Ctr, Utrecht, Netherlands

[2] German Inst Human Nutr, Potsdam, Germany

[3] German Canc Res Ctr, D-6900 Heidelberg, Germany

[4] Basque Govt, CIBERESP, San Sebastian, Spain

[5] Inst Biol Lille, Lille, France

[6] Murcia Reg Hlth Council, Murcia, Spain

[7] CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain

[8] Univ Oxford, Oxford, England

[9] Natl Inst Publ Hlth & Environm, NL-3720 BA Bilthoven, Netherlands

[10] CESP Ctr Res Epidemiol & Populat Hlth, INSERM, Villejuif, France

[11] Lund Univ, Malmo, Sweden

[12] Univ London Imperial Coll Sci Technol & Med, London, England

[13] Dept Epidemiol, Barcelona, Spain

[14] Danish Canc Soc, Copenhagen, Denmark

[15] Univ Cambridge, Cambridge, England

[16] Fdn IRCCS Ist Nazl Tumori Milan, Milan, Italy

[17] Andalusian Sch Publ Hlth, Granada, Spain

[18] Sch Publ Hlth, Aarhus, Denmark

[19] Canc Res & Prevent Inst ISPO, Florence, Italy

[20] Univ Naples Federico II, Naples, Italy

[21] Consejeria Salud & Serv Sanitarios, Oviedo, Spain

[22] Umea Univ, Umea, Sweden

[23] Int Agcy Res Canc, F-69372 Lyon, France

[24] Ctr Canc Prevent CPO Piemonte, Turin, Italy

[25] Civile MP Arezzo Hosp, Ragusa, Italy

[26] Addenbrookes Hosp, Cambridge, England

[27] Wageningen Univ, Wageningen, Netherlands

来源：

JOURNAL OF INTERNAL MEDICINE | 2012年 / 272卷 / 04期

基金：

瑞典研究理事会; 英国医学研究理事会;

关键词：

alcohol consumption; beverage; BMI; sex; type; 2; diabetes; INSULIN SENSITIVITY; POSTMENOPAUSAL WOMEN; DRINKING PATTERNS; PHYSICAL-ACTIVITY; DIETARY-INTAKE; CANCER; ADIPONECTIN; MELLITUS; OVERWEIGHT; COHORT;

D O I：

10.1111/j.1365-2796.2012.02532.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Beulens JWJ, van der Schouw YT, Bergmann MM, Rohrmann S, B Schulze M, Buijsse B, Grobbee DE, Arriola L, Cauchi S, Tormo M-J, Allen NE, van der A DL, Balkau B, Boeing H, Clavel-Chapelon F, de Lauzon-Guillan B, Franks P, Froguel P, Gonzales C, Halkjaer J, Huerta JM, Kaaks R, Key TJ, Khaw KT, Krogh V, Molina-Montes E, Nilsson P, Overvad K, Palli D, Panico S, Ramon Quiros J, Ronaldsson O, Romieu I, Romaguera D, Sacerdote C, Sanchez M-J, Spijkerman AMW, Teucher B, Tjonneland A, Tumino R, Sharp S, Forouhi NG, Langenberg C, Feskens EJM, Riboli E, Wareham NJ (University Medical Center Utrecht, The Netherlands; German Institute of Human Nutrition, Potsdam-Rehbrucke, Germany; German Cancer Research Centre, Heidelberg, Germany; Basque Government, San Sebastian, CIBERESP, Spain; Institut de Biologie de Lille, Lille, France; Murcia Regional Health Council, Murcia, Spain; CIBER Epidemiologia y Salud Publica (CIBERESP), Spain; University of Oxford, Oxford, UK; National Institute of Public Health and the Environment, Bilthoven, The Netherlands; Inserm, CESP Centre for Research in Epidemiology and Population Health, Villejuif Cedex, France; Lund University, Malmo, Sweden; Imperial College, London, UK; Department of Epidemiology, Barcelona, Spain; Danish Cancer Society, Copenhagen, Denmark; University of Cambridge, Cambridge, UK; Fondazione IRCCS Istituto Nazionale Tumori Milan, Milan, Italy; Andalusian School of Public Health, Granada, Spain; School of Public Health, Aarhus, Denmark; Cancer Research and Prevention Institute (ISPO), Florence, Italy; Universita Federico II, Napoli, Italy; Consejeria de Salud y Servicios Sanitarios, Oviedo-Asturias, Spain; Umea University, Umea, Sweden; International Agency for Research of Cancer, Lyon, France; Center for Cancer Prevention (CPO-Piemonte), Torino, Italy; Civile - M.P. Arezzo Hospital, Ragusa, Italy; Addenbrookes Hospital, Cambridge, UK; and Wageningen University, Wageningen, The Netherlands). Alcohol consumption and risk of type 2 diabetes in European men and women: influence of beverage type and body size. The EPICInterAct study. J Intern Med 2012; 272: 358370. Objective: To investigate the association between alcohol consumption and type 2 diabetes, and determine whether this is modified by sex, body mass index (BMI) and beverage type. Design: Multicentre prospective casecohort study. Setting: Eight countries from the European Prospective Investigation into Cancer and Nutrition cohort. Subjects: A representative baseline sample of 16 154 participants and 12 403 incident cases of type 2 diabetes. Interventions: Alcohol consumption assessed using validated dietary questionnaires. Main outcome measures: Occurrence of type 2 diabetes based on multiple sources (mainly self-reports), verified against medical information. Results: Amongst men, moderate alcohol consumption was nonsignificantly associated with a lower incidence of diabetes with a hazard ratio (HR) of 0.90 (95% CI: 0.781.05) for 6.112.0 versus 0.16.0 g day-1, adjusted for dietary and diabetes risk factors. However, the lowest risk was observed at higher intakes of 24.196.0 g day-1 with an HR of 0.86 (95% CI: 0.750.98). Amongst women, moderate alcohol consumption was associated with a lower incidence of diabetes with a hazard ratio of 0.82 (95% CI: 0.720.92) for 6.112.0 g day-1 (P interaction gender <0.01). The inverse association between alcohol consumption and diabetes was more pronounced amongst overweight (BMI = 25 kg m-2) than normal-weight men and women (P interaction < 0.05). Adjusting for waist and hip circumference did not alter the results for men, but attenuated the association for women (HR=0.90, 95% CI: 0.791.03 for 6.112.0 g day-1). Wine consumption for men and fortified wine consumption for women were most strongly associated with a reduced risk of diabetes. Conclusions: The results of this study show that moderate alcohol consumption is associated with a lower risk of type 2 diabetes amongst women only. However, this risk reduction is in part explained by fat distribution. The relation between alcohol consumption and type 2 diabetes was stronger for overweight than normal-weight women and men.

引用

页码：358 / 370

页数：13

共 40 条

[1] Alcohol consumption and risk of type 2 diabetes mellitus among US male physicians [J].