Fabrication and properties of porous scaffold of magnesium phosphate/polycaprolactone biocomposite for bone tissue engineering

被引：69

作者：

Wu, Fan ^{[1
]}

Liu, Changsheng ^{[2
,3
]}

O'Neill, Brian ^{[1
]}

Wei, Jie ^{[2
,3
]}

Ngothai, Yung ^{[1
]}

机构：

[1] Univ Adelaide, Sch Chem Engn, Adelaide, SA 5005, Australia

[2] E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

[3] E China Univ Sci & Technol, Minist Educ, Engn Res Ctr Biomed Mat, Shanghai 200237, Peoples R China

来源：

APPLIED SURFACE SCIENCE | 2012年 / 258卷 / 19期

关键词：

PCL; Magnesium phosphate; Porous scaffold; Degradation; IN-VIVO DEGRADATION; COMPOSITE SCAFFOLDS; MECHANICAL-PROPERTIES; POLYCAPROLACTONE; OSTEOBLAST; WOLLASTONITE; SURFACES; CALCIUM;

D O I：

10.1016/j.apsusc.2012.04.094

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

In this study, porous scaffolds made of magnesium phosphate (MP)/polycaprolactone (PCL) biocomposite were developed for bone tissue engineering applications. The composite scaffolds were fabricated by the particulate leaching method using sodium chloride particles as porogen. The obtained scaffold with porosity around 73% presents a porous structure with interconnected open pores. Hydrophilicity of the scaffolds was enhanced by the incorporation of MP component as demonstrated by the water contact angle measurement. The results of the in vitro degradation study show that the MP/PCL composite scaffolds degraded faster than PCL scaffolds in phosphate buffered saline (PBS). In addition, the degradation rate of the scaffolds could be tuned by adjusting the content of MP component in the composite. The results indicate that the MP/PCL composite scaffold has a potential application in bone tissue engineering. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：7589 / 7595

页数：7

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