Impact of 5-HT3 receptor antagonists on peripheral and central diseases

被引：50
作者：
Fakhfouri, Gohar [2 ]
Rahimian, Reza [1 ]
Ghia, Jean-Eric [3 ]
Khan, Waliul I. [4 ]
Dehpour, Ahmad R. [1 ]
机构：
[1] Univ Tehran Med Sci, Sch Med, Dept Pharmacol, Tehran, Iran
[2] Shahid Beheshti Univ Med Sci, Sch Med, Dept Pharmacol, Tehran, Iran
[3] Univ Manitoba, Fac Med, Dept Immunol & Internal Med, Gastroenterol Sect, Winnipeg, MB, Canada
[4] McMaster Univ, Dept Pathol & Mol Med, Farncombe Family Digest Hlth Res Inst, Hamilton, ON L8S 4L8, Canada
来源：
DRUG DISCOVERY TODAY | 2012年 / 17卷 / 13-14期
关键词：
EXPERIMENTAL COLITIS; INDUCED ARTHRITIS; NERVOUS-SYSTEM; SEROTONIN; TROPISETRON; NEUROTOXICITY; CELLS; BRAIN; 5-HYDROXYTRYPTAMINE; GRANISETRON;
D O I：
10.1016/j.drudis.2012.02.009
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In this article we discuss the novel pharmacological aspects of 5-HT3 receptor antagonists. Commonly used to counteract chemotherapy-induced emesis, these agents now appear to be reaching out for newer indications. Studies have reported neuroprotective and anti-inflammatory properties in vitro and in vivo. 5-HT3 receptor antagonists can modulate the immune-inflammatory axis through blockade of 5-HT3 receptors present on immune cells. We review evidence addressing the effects of these drugs on peripheral inflammatory diseases, including asthma, rheumatoid diseases, inflammatory bowel disease and sepsis in addition to diabetes and CNS disorders, including Alzheimer's disease (AD), seizure and stroke.
引用
收藏
页码：741 / 747
页数：7
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