Impact of 5-HT3 receptor antagonists on peripheral and central diseases

被引：50

作者：

Fakhfouri, Gohar ^{[2
]}

Rahimian, Reza ^{[1
]}

Ghia, Jean-Eric ^{[3
]}

Khan, Waliul I. ^{[4
]}

Dehpour, Ahmad R. ^{[1
]}

机构：

[1] Univ Tehran Med Sci, Sch Med, Dept Pharmacol, Tehran, Iran

[2] Shahid Beheshti Univ Med Sci, Sch Med, Dept Pharmacol, Tehran, Iran

[3] Univ Manitoba, Fac Med, Dept Immunol & Internal Med, Gastroenterol Sect, Winnipeg, MB, Canada

[4] McMaster Univ, Dept Pathol & Mol Med, Farncombe Family Digest Hlth Res Inst, Hamilton, ON L8S 4L8, Canada

来源：

DRUG DISCOVERY TODAY | 2012年 / 17卷 / 13-14期

关键词：

EXPERIMENTAL COLITIS; INDUCED ARTHRITIS; NERVOUS-SYSTEM; SEROTONIN; TROPISETRON; NEUROTOXICITY; CELLS; BRAIN; 5-HYDROXYTRYPTAMINE; GRANISETRON;

D O I：

10.1016/j.drudis.2012.02.009

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In this article we discuss the novel pharmacological aspects of 5-HT3 receptor antagonists. Commonly used to counteract chemotherapy-induced emesis, these agents now appear to be reaching out for newer indications. Studies have reported neuroprotective and anti-inflammatory properties in vitro and in vivo. 5-HT3 receptor antagonists can modulate the immune-inflammatory axis through blockade of 5-HT3 receptors present on immune cells. We review evidence addressing the effects of these drugs on peripheral inflammatory diseases, including asthma, rheumatoid diseases, inflammatory bowel disease and sepsis in addition to diabetes and CNS disorders, including Alzheimer's disease (AD), seizure and stroke.

引用

页码：741 / 747

页数：7

共 60 条

[1] Serotonin and epilepsy [J].

Bagdy, Gyorgy ;

Kecskemeti, Valeria ;

Riba, Pal ;

Jakus, Rita .

JOURNAL OF NEUROCHEMISTRY, 2007, 100 (04) :857-873

[2] Blockade of 5-HT3 receptor with MDL72222 and Y25130 reduces β-amyloid protein (25-35)-induced neurotoxicity in cultured rat cortical neurons [J].

Ban, JY ;

Seong, YH .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2005, 520 (1-3) :12-21

[3] Glucocorticoid resistance in inflammatory diseases [J].

Barnes, Peter J. ;

Adcock, Ion M. .

LANCET, 2009, 373 (9678) :1905-1917

[4]

Butler Claire A., 2007, Inflammation & Allergy Drug Targets, V6, P127

[5] Detrimental effects of tropisetron on permanent ischemic stroke in the rat [J].

Candelario-Jalil, Eduardo ;

Munoz, Eduardo ;

Fiebich, Bernd L. .

BMC NEUROSCIENCE, 2008, 9 (1)

[6] Further studies on the interaction of the 5-hydroxytryptamine3 (5-HT3) receptor with arylpiperazine ligands.: Development of a new 5-HT3 receptor ligand showing potent acetylcholinesterase inhibitory properties [J].

Cappelli, A ;

Gallelli, A ;

Manini, M ;

Anzini, M ;

Mennuni, L ;

Makovec, F ;

Menziani, MC ;

Alcaro, S ;

Ortuso, F ;

Vomero, S .

JOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (10) :3564-3575

[7] Dose-related impairment of spatial learning by intrahippocampal scopolamine: Antagonism by ondansetron, a 5-HT3 receptor antagonist [J].

Carli, M ;

Luschi, R ;

Samanin, R .

BEHAVIOURAL BRAIN RESEARCH, 1997, 82 (02) :185-194

[8] Hyperglycemia induced by pharmacological activation of central Serotonergic pathways depends on the functional integrity of brain CRH system and 5-HT3 receptors [J].

Carvalho, F ;

Barros, D ;

Silva, J ;

Rezende, E ;

Soares, M ;

Fregoneze, J ;

de Castro-e-Silva, E .

HORMONE AND METABOLIC RESEARCH, 2005, 37 (08) :482-488

[9] Central 5-HT3 receptor stimulation by m-CPBG increases blood glucose in rats [J].

Carvalho, F ;

Macêdo, D ;

Bandeira, I ;

Maldonado, I ;

Salles, L ;

Azevedo, MF ;

Rocha, MA ;

Fregoneze, JB ;

De Castro-e-Silva, E .

HORMONE AND METABOLIC RESEARCH, 2002, 34 (02) :55-61

[10]

Cloez-Tayarani Isabelle, 2006, Current Immunology Reviews, V2, P27, DOI 10.2174/157339506775471893

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