Construction of the basic skeleton of ophiobolin A and variecolin

被引：23

作者：

Li, Ke ^{[1
]}

Wang, Cheng ^{[1
]}

Yin, Gang ^{[1
]}

Gao, Shuanhu ^{[1
,2
]}

机构：

[1] E China Normal Univ, Dept Chem, Shanghai Key Lab Green Chem & Chem Proc, Shanghai 200062, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2013年 / 11卷 / 43期

关键词：

ENYNE METATHESIS; SAMARIUM(II) IODIDE; SEQUENCED REACTIONS; RING COMPOUNDS; SESTERTERPENES; SYSTEMS; CORE; CYCLOADDITION; HETEROCYCLES; 4-EXO-DIG;

D O I：

10.1039/c3ob41693c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ophiobolin and variecolin type sesterterpenoids belong to cyclooctane-containing natural products. Both sesterterpenoids have challenging structures and appealing biological activities. We envisioned that a key tandem ring closing metathesis of dienynes could provide the basic skeleton of ophiobolin A and variecolin. We report herein the detailed reactivities of the dienynes which furnished the 5-8-5 and 5-8-6-5 rings efficiently.

引用

页码：7550 / 7558

页数：9

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