Public health implications from COGS and potential for risk stratification and screening

被引：105

作者：

Burton, Hilary ^{[1
]}

Chowdhury, Susmita ^{[1
]}

Dent, Tom ^{[1
]}

Hall, Alison ^{[1
]}

Pashayan, Nora ^{[2
]}

Pharoah, Paul ^{[3
,4
]}

机构：

[1] PHG Fdn Fdn Genom & Populat Hlth, Cambridge, England

[2] UCL, Dept Appl Hlth Res, London, England

[3] Univ Cambridge, Inst Publ Hlth, Dept Publ Hlth & Primary Care, Cambridge, England

[4] Univ Cambridge, Dept Oncol, Cambridge, England

来源：

NATURE GENETICS | 2013年 / 45卷 / 04期

关键词：

BREAST-CANCER; PROSTATE; SURVIVAL;

D O I：

10.1038/ng.2582

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The PHG Foundation led a multidisciplinary program, which used results from COGS research identifying genetic variants associated with breast, ovarian and prostate cancers to model risk-stratified prevention for breast and prostate cancers. Implementing such strategies would require attention to the use and storage of genetic information, the development of risk assessment tools, new protocols for consent and programs of professional education and public engagement.

引用

页码：349 / 351

页数：3

共 20 条

[1]

[Anonymous], 2013, NAT GENET, DOI [10.1038/ng.2592, DOI 10.1038/NG.2592]

[2] Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history:: A combined analysis of 22 studies [J].

Antoniou, A ;

Pharoah, PDP ;

Narod, S ;

Risch, HA ;

Eyfjord, JE ;

Hopper, JL ;

Loman, N ;

Olsson, H ;

Johannsson, O ;

Borg, Å ;

Pasini, B ;

Radice, P ;

Manoukian, S ;

Eccles, DM ;

Tang, N ;

Olah, E ;

Anton-Culver, H ;

Warner, E ;

Lubinski, J ;

Gronwald, J ;

Gorski, B ;

Tulinius, H ;

Thorlacius, S ;

Eerola, H ;

Nevanlinna, H ;

Syrjäkoski, K ;

Kallioniemi, OP ;

Thompson, D ;

Evans, C ;

Peto, J ;

Lalloo, F ;

Evans, DG ;

Easton, DF .

AMERICAN JOURNAL OF HUMAN GENETICS, 2003, 72 (05) :1117-1130

[3] Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer [J].

Bojesen, Stig E. ;

Pooley, Karen A. ;

Johnatty, Sharon E. ;

Beesley, Jonathan ;

Michailidou, Kyriaki ;

Tyrer, Jonathan P. ;

Edwards, Stacey L. ;

Pickett, Hilda A. ;

Shen, Howard C. ;

Smart, Chanel E. ;

Hillman, Kristine M. ;

Mai, Phuong L. ;

Lawrenson, Kate ;

Stutz, Michael D. ;

Lu, Yi ;

Karevan, Rod ;

Woods, Nicholas ;

Johnston, Rebecca L. ;

French, Juliet D. ;

Chen, Xiaoqing ;

Weischer, Maren ;

Nielsen, Sune F. ;

Maranian, Melanie J. ;

Ghoussaini, Maya ;

Ahmed, Shahana ;

Baynes, Caroline ;

Bolla, Manjeet K. ;

Wang, Qin ;

Dennis, Joe ;

McGuffog, Lesley ;

Barrowdale, Daniel ;

Lee, Andrew ;

Healey, Sue ;

Lush, Michael ;

Tessier, Daniel C. ;

Vincent, Daniel ;

Bacot, Francis ;

Vergote, Ignace ;

Lambrechts, Sandrina ;

Despierre, Evelyn ;

Risch, Harvey A. ;

Gonzalez-Neira, Anna ;

Rossing, Mary Anne ;

Pita, Guillermo ;

Doherty, Jennifer A. ;

Alvarez, Nuria ;

Larson, Melissa C. ;

Fridley, Brooke L. ;

Schoof, Nils ;

Chang-Claude, Jenny .

NATURE GENETICS, 2013, 45 (04) :371-384

[4]

Burton H., 2012, ITAL J PUBLIC HLTH, V9, P4

[5] Incorporating genomics into breast and prostate cancer screening: assessing the implications [J].

Chowdhury, Susmita ;

Dent, Tom ;

Pashayan, Nora ;

Hall, Alison ;

Lyratzopoulos, Georgios ;

Hallowell, Nina ;

Hall, Per ;

Pharoah, Paul ;

Burton, Hilary .

GENETICS IN MEDICINE, 2013, 15 (06) :423-432

[6] Stratified Cancer Screening: The Practicalities of Implementation [J].

Dent, T. ;

Jbilou, J. ;

Rafi, I. ;

Segnan, N. ;

Tornberg, S. ;

Chowdhury, S. ;

Hall, A. ;

Lyratzopoulos, G. ;

Eeles, R. ;

Eccles, D. ;

Hallowell, N. ;

Pashayan, N. ;

Pharoah, P. ;

Burton, H. .

PUBLIC HEALTH GENOMICS, 2013, 16 (03) :94-99

[7] Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array [J].

Eeles, Rosalind A. ;

Al Olama, Ali Amin ;

Benlloch, Sara ;

Saunders, Edward J. ;

Leongamornlert, Daniel A. ;

Tymrakiewicz, Malgorzata ;

Ghoussaini, Maya ;

Luccarini, Craig ;

Dennis, Joe ;

Jugurnauth-Little, Sarah ;

Dadaev, Tokhir ;

Neal, David E. ;

Hamdy, Freddie C. ;

Donovan, Jenny L. ;

Muir, Ken ;

Giles, Graham G. ;

Severi, Gianluca ;

Wiklund, Fredrik ;

Gronberg, Henrik ;

Haiman, Christopher A. ;

Schumacher, Fredrick ;

Henderson, Brian E. ;

Le Marchand, Loic ;

Lindstrom, Sara ;

Kraft, Peter ;

Hunter, David J. ;

Gapstur, Susan ;

Chanock, Stephen J. ;

Berndt, Sonja I. ;

Albanes, Demetrius ;

Andriole, Gerald ;

Schleutker, Johanna ;

Weischer, Maren ;

Canzian, Federico ;

Riboli, Elio ;

Key, Tim J. ;

Travis, Ruth C. ;

Campa, Daniele ;

Ingles, Sue A. ;

John, Esther M. ;

Hayes, Richard B. ;

Pharoah, Paul D. P. ;

Pashayan, Nora ;

Khaw, Kay-Tee ;

Stanford, Janet L. ;

Ostrander, Elaine A. ;

Signorello, Lisa B. ;

Thibodeau, Stephen N. ;

Schaid, Dan ;

Maier, Christiane .

NATURE GENETICS, 2013, 45 (04) :385-391

[8] Breast Cancer in Young Women: Poor Survival Despite Intensive Treatment [J].

Fredholm, Hanna ;

Eaker, Sonja ;

Frisell, Jan ;

Holmberg, Lars ;

Fredriksson, Irma ;

Lindman, Henrik .

PLOS ONE, 2009, 4 (11) :A38-A46

[9] Functional Variants at the 11q13 Risk Locus for Breast Cancer Regulate Cyclin D1 Expression through Long-Range Enhancers [J].

French, Juliet D. ;

Ghoussaini, Maya ;

Edwards, Stacey L. ;

Meyer, Kerstin B. ;

Michailidou, Kyriaki ;

Ahmed, Shahana ;

Khan, Sofia ;

Maranian, Mel J. ;

O'Reilly, Martin ;

Hillman, Kristine M. ;

Betts, Joshua A. ;

Carro, Thomas ;

Bailey, Peter J. ;

Dicks, Ed ;

Beesley, Jonathan ;

Tyrer, Jonathan ;

Maia, Ana-Teresa ;

Beck, Andrew ;

Knoblauch, Nicholas W. ;

Chen, Constance ;

Kraft, Peter ;

Barnes, Daniel ;

Gonzalez-Neira, Anna ;

Rosario Alonso, M. ;

Herrero, Daniel ;

Tessier, Daniel C. ;

Vincent, Daniel ;

Bacot, Francois ;

Luccarini, Craig ;

Baynes, Caroline ;

Conroy, Don ;

Dennis, Joe ;

Bolla, Manjeet K. ;

Wang, Qin ;

Hopper, John L. ;

Southey, Melissa C. ;

Schmidt, Marjanka K. ;

Broeks, Annegien ;

Verhoef, Senno ;

Cornelissen, Sten ;

Muir, Kenneth ;

Lophatananon, Artitaya ;

Stewart-Brown, Sarah ;

Siriwanarangsan, Pomthep ;

Fasching, Peter A. ;

Loehberg, Christian R. ;

Ekici, Arif B. ;

Beckmann, Matthias W. ;

Peto, Julian ;

Silva, Isabel dos Santos .

AMERICAN JOURNAL OF HUMAN GENETICS, 2013, 92 (04) :489-503

[10] Genome-wide association studies identify four ER negative-specific breast cancer risk loci [J].

Garcia-Closas, Montserrat ;

Couch, Fergus J. ;

Lindstrom, Sara ;

Michailidouo, Kyriaki ;

Schmidt, Marjanka K. ;

Brook, Mark N. ;

Orr, Nick ;

Rhie, Suhn Kyong ;

Riboli, Elio ;

Feigelson, Heather S. ;

Le Marchand, Loic ;

Buring, Julie E. ;

Eccles, Diana ;

Miron, Penelope ;

Fasching, Peter A. ;

Brauch, Hiltrud ;

Chang-Claude, Jenny ;

Carpenter, Jane ;

Godwin, Andrew K. ;

Nevanlinna, Heli ;

Giles, Graham G. ;

Cox, Angela ;

Hopper, John L. ;

Bolla, Manjeet K. ;

Wang, Qin ;

Dennis, Joe ;

Dicks, Ed ;

Howat, Will J. ;

Schoof, Nils ;

Bojesen, Stig E. ;

Lambrechts, Diether ;

Broeks, Annegien ;

Andrulis, Irene L. ;

Guenel, Pascal ;

Burwinkel, Barbara ;

Sawyer, Elinor J. ;

Hollestelle, Antoinette ;

Fletcher, Olivia ;

Winqvist, Robert ;

Brenner, Hermann ;

Mannermaa, Arto ;

Hamann, Ute ;

Meindl, Alfons ;

Lindblom, Annika ;

Zheng, Wei ;

Devillee, Peter ;

Goldberg, Mark S. ;

Lubinski, Jan ;

Kristensen, Vessela ;

Swerdlow, Anthony .

NATURE GENETICS, 2013, 45 (04) :392-398

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