Bovine innate and adaptive immune responses against Escherichia coli 0157:H7 and vaccination strategies to reduce faecal shedding in ruminants

被引：31
作者：
Walle, Kris Vande [1 ]
Vanrompay, Daisy [2 ]
Cox, Eric [1 ]
机构：
[1] Univ Ghent, Fac Vet Med, Immunol Lab, B-9860 Merelbeke, Belgium
[2] Univ Ghent, Fac Biosci Engn, Dept Mol Biotechnol, B-9000 Ghent, Belgium
来源：
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY | 2013年 / 152卷 / 1-2期
关键词：
Escherichia coli; EHEC; Ruminants; Immunity; Vaccines; III SECRETED PROTEINS; NATURALLY INFECTED CATTLE; SHIGA-LIKE TOXINS; FEEDLOT CATTLE; O157H7; COLONIZATION; ANTIBODY-RESPONSES; INTRAEPITHELIAL LYMPHOCYTES; INTESTINAL COLONIZATION; SIDEROPHORE RECEPTOR; HOMOLOGOUS STRAIN;
D O I：
10.1016/j.vetimm.2012.09.028
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Enterohaemorrhagic E. coli (EHEC) 0157:H7 is a zoonotic pathogen of worldwide importance causing foodborne infections with possibly life-threatening consequences in humans, such as haemorrhagic colitis and in a small percentage of zoonotic cases, haemolytic-uremic syndrome (HUS). Ruminants are an important reservoir of EHEC and human infections are most frequently associated with direct or indirect contact with ruminant faeces. A thorough understanding of the host-bacterium interaction in ruminants could lead to the development of novel interventions strategies, including innovative vaccines. This review aims to present the current knowledge regarding innate and adaptive immune responses in EHEC colonized ruminants. In addition, results on vaccination strategies in ruminants aiming at reduction of EHEC shedding are reviewed. (C) 2012 Elsevier B.V. All rights reserved.
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收藏
页码：109 / 120
页数：12
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