Inhibitors of Lysine Biosynthesis as Antibacterial Agents

被引：93

作者：

Hutton, Craig A. ^{[1
]}

Southwood, Timothy J. ^{[1
]}

Turner, Jennifer J. ^{[1
]}

机构：

[1] Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2003年 / 3卷 / 02期

关键词：

Lysine; DAP pathway; diaminopimelate; antibiotics; enzyme inhibitors;

D O I：

10.2174/1389557033405359

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Bacterial biosynthesis of lysine has come under increased scrutiny as a target for novel antibacterial agents as it provides both lysine for protein synthesis and meso-diaminopimelate for construction of the bacterial peptidoglycan cell wall. Recent studies of the enzymes of the lysine biosynthetic pathway, development of inhibitors and investigations of their antibacterial properties are discussed.

引用

页码：115 / 127

页数：13

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