Inhibitors of Lysine Biosynthesis as Antibacterial Agents

被引：93
作者：
Hutton, Craig A. [1 ]
Southwood, Timothy J. [1 ]
Turner, Jennifer J. [1 ]
机构：
[1] Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2003年 / 3卷 / 02期
关键词：
Lysine; DAP pathway; diaminopimelate; antibiotics; enzyme inhibitors;
D O I：
10.2174/1389557033405359
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Bacterial biosynthesis of lysine has come under increased scrutiny as a target for novel antibacterial agents as it provides both lysine for protein synthesis and meso-diaminopimelate for construction of the bacterial peptidoglycan cell wall. Recent studies of the enzymes of the lysine biosynthetic pathway, development of inhibitors and investigations of their antibacterial properties are discussed.
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收藏
页码：115 / 127
页数：13
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