Ganglioside reactive antibodies of IgG and IgM class in sera of patients with differentiated thyroid cancer

被引：6

作者：

Lewartowska, A ^{[1
]}

Pacuszka, T ^{[1
]}

Adler, G ^{[1
]}

Panasiewicz, M ^{[1
]}

Wojciechowska, W ^{[1
]}

机构：

[1] Med Ctr Postgrad Educ, Dept Clin Biochem, PL-01813 Warsaw, Poland

来源：

IMMUNOLOGY LETTERS | 2002年 / 80卷 / 02期

关键词：

gangliosides; anti-ganglioside antibodies; thyroid; cancer;

D O I：

10.1016/S0165-2478(01)00300-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We searched for the presence of ganglioside reactive antibodies in sera of patients with differentiated thyroid cancer (DTC). Sera were screened by ELISA with plates coated with GM3(NeuAc), GM3(NeuGe), GM2, GM1, FucGM1, GD3, GD1a or GD1b gangliosides. Ganglioside reactive antibodies were detected more frequently in sera of patients with DTC than in sera of healthy persons, in keeping with the possibility of autoimmunization during carcinogenesis. Antibodies of IgM and IgG classes reactive with FucGM1 occurred most often. However. the infrequent occurrence of ganglioside reactive antibodies, their low titer and lack of correlation between their presence and clinical condition of the patients indicate that determination of these antibodies has no diagnostic value in DTC. (C) 2002 Elsevier Science B.V. All, rights reserved.

引用

页码：129 / 132

页数：4

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