Rapid subcutaneous desensitization for the management of delayed hypersensitivity reactions to omalizumab:A case report

被引：7
作者：
Gan, Hui [1 ]
Wang, Ling [1 ]
Fu, Wei [1 ]
Zhang, Jinjin [1 ]
Yu, Mingxia [2 ]
Liu, Guanghui [1 ]
机构：
[1] Wuhan Univ, Dept Allergy, Zhongnan Hosp, Wuhan, Hubei, Peoples R China
[2] Wuhan Univ, Dept Clin Lab, Zhongnan Hosp, Wuhan, Hubei, Peoples R China
来源：
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS | 2019年 / 44卷 / 03期
关键词：
delayed hypersensitivity; desensitization; drug allergy; omalizumab; THERAPY; ASTHMA;
D O I：
10.1111/jcpt.12827
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
What is known and objective Omalizumab is effective as an add-on drug to treat severe persistent allergic asthma. However, delayed hypersensitivity reactions to omalizumab may deprive patients of its use. Rapid subcutaneous desensitization could be a solution. Case description A 61-year-old man developed a delayed allergy to omalizumab after the first injection. A 14-step desensitization procedure was applied to the patient and was successful. What is new and conclusion Delayed hypersensitivity reactions to omalizumab are rare, but they may cause the interruption of drug usage. Desensitization to omalizumab could be a possible solution.
引用
收藏
页码：486 / 488
页数：3
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