Recent progress in bovine somatic cell nuclear transfer

被引：36

作者：

Akagi, Satoshi ^{[1
]}

Geshi, Masaya ^{[1
]}

Nagai, Takashi ^{[1
]}

机构：

[1] Natl Agr & Food Res Org, Inst Livestock & Grassland Sci, Tsukuba, Ibaraki 3050901, Japan

来源：

ANIMAL SCIENCE JOURNAL | 2013年 / 84卷 / 03期

关键词：

bovine; cloning; reprogramming; somatic cell nuclear transfer; IN-VITRO DEVELOPMENT; FULL-TERM DEVELOPMENT; HISTONE DEACETYLASE INHIBITOR; CLONED TRANSGENIC CALVES; TRANSFER EMBRYOS; DONOR CELLS; GENE-EXPRESSION; CLONING EFFICIENCY; DNA METHYLATION; FIBROBLAST CELLS;

D O I：

10.1111/asj.12035

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

Bovine somatic cell nuclear transfer (SCNT) embryos can develop to the blastocyst stage at a rate similar to that of embryos produced by in vitro fertilization. However, the full-term developmental rate of SCNT embryos is very low, owing to the high embryonic and fetal losses after embryo transfer. In addition, increased birth weight and postnatal mortality are observed at high rates in cloned calves. The low efficiency of SCNT is probably attributed to incomplete reprogramming of the donor nucleus and most of the developmental problems of clones are thought to be caused by epigenetic defects. Applications of SCNT will depend on improvement in the efficiency of production of healthy cloned calves. In this review, we discuss problems and recent progress in bovine SCNT.

引用

页码：191 / 199

页数：9

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