Real-Time Biosensor Platform Based on Novel Sandwich Graphdiyne for Ultrasensitive Detection of Tumor Marker

被引：127

作者：

Xu, Jing ^{[1
]}

Liu, Yinbing ^{[1
]}

Huang, Ke-Jing ^{[2
]}

Hou, Yang-Yang ^{[1
]}

Sun, Xiaoxuan ^{[1
]}

Li, Jiaqiang ^{[3
]}

机构：

[1] Xinyang Normal Univ, Coll Chem & Chem Engn, Xinyang 464000, Peoples R China

[2] Guangxi Minzu Univ, Sch Chem & Chem Engn, Key Lab Guangxi Coll & Univ Food Safety & Pharmace, Key Lab Chem & Engn Forest Prod,Guangxi Key Lab Ch, Nanning 530008, Peoples R China

[3] King Abdullah Univ Sci & Technol, Adv Membranes & Porous Mat Ctr, Phys Sci & Engn Div, Thuwal 239556900, Saudi Arabia

来源：

ANALYTICAL CHEMISTRY | 2022年 / 94卷 / 49期

关键词：

BIOFUEL CELLS; HIGH-POWER; APTAMER; SELECTION; ASSAY;

D O I：

10.1021/acs.analchem.2c04278

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Realization of a highly sensitive analysis and sensing platform is important for early-stage tumor diagnosis. In this work, a self-powered biosensor with a novel sandwich graphdiyne (SGDY) combined with an aptamer-specific recognition function was developed to sensitively and accurately detect tumor markers. Results indicated that the detection limits of microRNA (miRNA)-21 and miRNA-141 were 0.15 and 0.30 fM (S/N = 3) in the linear range of 0.05-10000 and 1-10000 fM, respectively. The newly designed platform has great promise for early-stage tumor diagnosis.

引用

页码：16980 / 16986

页数：7

共 50 条

[41] Foot-and-mouth disease virus detection on a handheld real-time polymerase chain reaction platform [J].

Hole, Kate ;

Nfon, Charles .

TRANSBOUNDARY AND EMERGING DISEASES, 2019, 66 (04) :1789-1795

[42] Development, validation and utility of conventional and real-time PCR based marker for the detection of Bipolaris oryzae causing brown spot disease of rice [J].

Singh, Kartar ;

Sharma, Sapna ;

Tyagi, Aditya ;

Gupta, Sangeeta ;

Bashyal, Bishnu M. ;

Gurjar, M. S. ;

Saharan, M. S. ;

Choudhary, Manoj ;

Aggarwal, Rashmi .

AUSTRALASIAN PLANT PATHOLOGY, 2025, 54 (02) :101-110

[43] Ultrasensitive aptamer biosensor for arsenic (III) detection based on label-free triple-helix molecular switch and fluorescence sensing platform [J].

Pan, Jiafeng ;

Li, Qiong ;

Zhou, Danhua ;

Chen, Junhua .

TALANTA, 2018, 189 :370-376

[44] A novel magnetic fluorescent biosensor based on graphene quantum dots for rapid, efficient, and sensitive separation and detection of circulating tumor cells [J].

Cui, Fangchao ;

Ji, Jian ;

Sun, Jiadi ;

Wang, Jun ;

Wang, Haiming ;

Zhang, Yinzhi ;

Ding, Hong ;

Lu, Yong ;

Xu, Dan ;

Sun, Xiulan .

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2019, 411 (05) :985-995

[45] An ultrasensitive electrochemiluminescence biosensor for the detection of total bacterial count in environmental and biological samples based on a novel sulfur quantum dot luminophore [J].

Wang, Xiaobin ;

Zhao, Yuqing ;

Hua, Qing ;

Lu, Jiaojiao ;

Tang, Feiyan ;

Sun, Wenjie ;

Luan, Feng ;

Zhuang, Xuming ;

Tian, Chunyuan .

ANALYST, 2022, 147 (08) :1716-1721

[46] A novel electrochemical biosensor based on polyadenine modified aptamer for label-free and ultrasensitive detection of human breast cancer cells [J].

Wang, Kun ;

He, Meng-Qi ;

Zhai, Fu-Heng ;

He, Rong-Huan ;

Yu, Yong-Liang .

TALANTA, 2017, 166 :87-92

[47] Droplet digital PCR and real-time PCR for the sensitive and specific detection of Vibrio vulnificus based on the novel target genes [J].

Cui, Xinping ;

Zhou, Haibo ;

Lu, Zhaoxin ;

Hu, Antuo ;

Zhang, Shengyu ;

Bie, Xiaomei ;

Yang, Jun .

EUROPEAN FOOD RESEARCH AND TECHNOLOGY, 2024, 250 (07) :1891-1902

[48] Detection of goat meat adulteration by real-time PCR based on a reference primer [J].

Li, Ting Ting ;

Jalbani, Yar Muhammad ;

Zhang, Gui Lan ;

Zhao, Zhi Yong ;

Wang, Zhi Ying ;

Zhao, Xiao Yan ;

Chen, Ai Liang .

FOOD CHEMISTRY, 2019, 277 :554-557

[49] Shape Coding Microhydrogel for a Real-Time Mycotoxin Detection System Based on Smartphones [J].

Ji, Wanying ;

Zhang, Ziyu ;

Tian, Yu ;

Yang, Zhengchun ;

Cao, Zongsheng ;

Zhang, Lili ;

Qi, Yangyang ;

Chang, Jin ;

Zhang, Shufang ;

Wang, Hanjie .

ACS APPLIED MATERIALS & INTERFACES, 2019, 11 (08) :8584-8590

[50] Real-Time PCR Method for the Rapid Detection and Quantification of Pathogenic Staphylococcus Species Based on Novel Molecular Target Genes [J].

Kim, Eiseul ;

Yang, Seung-Min ;

Won, Ji-Eun ;

Kim, Da-Young ;

Kim, Da-Som ;

Kim, Hae-Yeong .

FOODS, 2021, 10 (11)

← 1 2 3 4 5 →