Real-Time Biosensor Platform Based on Novel Sandwich Graphdiyne for Ultrasensitive Detection of Tumor Marker

被引：127
作者：
Xu, Jing [1 ]
Liu, Yinbing [1 ]
Huang, Ke-Jing [2 ]
Hou, Yang-Yang [1 ]
Sun, Xiaoxuan [1 ]
Li, Jiaqiang [3 ]
机构：
[1] Xinyang Normal Univ, Coll Chem & Chem Engn, Xinyang 464000, Peoples R China
[2] Guangxi Minzu Univ, Sch Chem & Chem Engn, Key Lab Guangxi Coll & Univ Food Safety & Pharmace, Key Lab Chem & Engn Forest Prod,Guangxi Key Lab Ch, Nanning 530008, Peoples R China
[3] King Abdullah Univ Sci & Technol, Adv Membranes & Porous Mat Ctr, Phys Sci & Engn Div, Thuwal 239556900, Saudi Arabia
来源：
ANALYTICAL CHEMISTRY | 2022年 / 94卷 / 49期
关键词：
BIOFUEL CELLS; HIGH-POWER; APTAMER; SELECTION; ASSAY;
D O I：
10.1021/acs.analchem.2c04278
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Realization of a highly sensitive analysis and sensing platform is important for early-stage tumor diagnosis. In this work, a self-powered biosensor with a novel sandwich graphdiyne (SGDY) combined with an aptamer-specific recognition function was developed to sensitively and accurately detect tumor markers. Results indicated that the detection limits of microRNA (miRNA)-21 and miRNA-141 were 0.15 and 0.30 fM (S/N = 3) in the linear range of 0.05-10000 and 1-10000 fM, respectively. The newly designed platform has great promise for early-stage tumor diagnosis.
引用
收藏
页码：16980 / 16986
页数：7
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