Real-Time Biosensor Platform Based on Novel Sandwich Graphdiyne for Ultrasensitive Detection of Tumor Marker

被引：127

作者：

Xu, Jing ^{[1
]}

Liu, Yinbing ^{[1
]}

Huang, Ke-Jing ^{[2
]}

Hou, Yang-Yang ^{[1
]}

Sun, Xiaoxuan ^{[1
]}

Li, Jiaqiang ^{[3
]}

机构：

[1] Xinyang Normal Univ, Coll Chem & Chem Engn, Xinyang 464000, Peoples R China

[2] Guangxi Minzu Univ, Sch Chem & Chem Engn, Key Lab Guangxi Coll & Univ Food Safety & Pharmace, Key Lab Chem & Engn Forest Prod,Guangxi Key Lab Ch, Nanning 530008, Peoples R China

[3] King Abdullah Univ Sci & Technol, Adv Membranes & Porous Mat Ctr, Phys Sci & Engn Div, Thuwal 239556900, Saudi Arabia

来源：

ANALYTICAL CHEMISTRY | 2022年 / 94卷 / 49期

关键词：

BIOFUEL CELLS; HIGH-POWER; APTAMER; SELECTION; ASSAY;

D O I：

10.1021/acs.analchem.2c04278

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Realization of a highly sensitive analysis and sensing platform is important for early-stage tumor diagnosis. In this work, a self-powered biosensor with a novel sandwich graphdiyne (SGDY) combined with an aptamer-specific recognition function was developed to sensitively and accurately detect tumor markers. Results indicated that the detection limits of microRNA (miRNA)-21 and miRNA-141 were 0.15 and 0.30 fM (S/N = 3) in the linear range of 0.05-10000 and 1-10000 fM, respectively. The newly designed platform has great promise for early-stage tumor diagnosis.

引用

页码：16980 / 16986

页数：7

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