Real-Time Biosensor Platform Based on Novel Sandwich Graphdiyne for Ultrasensitive Detection of Tumor Marker

被引：111

作者：

Xu, Jing ^{[1
]}

Liu, Yinbing ^{[1
]}

Huang, Ke-Jing ^{[2
]}

Hou, Yang-Yang ^{[1
]}

Sun, Xiaoxuan ^{[1
]}

Li, Jiaqiang ^{[3
]}

机构：

[1] Xinyang Normal Univ, Coll Chem & Chem Engn, Xinyang 464000, Peoples R China

[2] Guangxi Minzu Univ, Sch Chem & Chem Engn, Key Lab Guangxi Coll & Univ Food Safety & Pharmace, Key Lab Chem & Engn Forest Prod,Guangxi Key Lab Ch, Nanning 530008, Peoples R China

[3] King Abdullah Univ Sci & Technol, Adv Membranes & Porous Mat Ctr, Phys Sci & Engn Div, Thuwal 239556900, Saudi Arabia

来源：

ANALYTICAL CHEMISTRY | 2022年 / 94卷 / 49期

关键词：

BIOFUEL CELLS; HIGH-POWER; APTAMER; SELECTION; ASSAY;

D O I：

10.1021/acs.analchem.2c04278

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Realization of a highly sensitive analysis and sensing platform is important for early-stage tumor diagnosis. In this work, a self-powered biosensor with a novel sandwich graphdiyne (SGDY) combined with an aptamer-specific recognition function was developed to sensitively and accurately detect tumor markers. Results indicated that the detection limits of microRNA (miRNA)-21 and miRNA-141 were 0.15 and 0.30 fM (S/N = 3) in the linear range of 0.05-10000 and 1-10000 fM, respectively. The newly designed platform has great promise for early-stage tumor diagnosis.

引用

页码：16980 / 16986

页数：7

共 50 条

[21] Coupled cantilever biosensor utilizing a novel approach to gap-method for real-time detection of E. coli in low concentrations [J].

Bukhari, Syed Ali Raza ;

Alaei, Elham ;

Lai, Yongjun .

SENSORS AND ACTUATORS B-CHEMICAL, 2025, 435

[22] Ultrasensitive prostate cancer marker PCA3 detection with impedimetric biosensor based on specific label-free aptamers [J].

Takita S. ;

Nabok A. ;

Mussa M. ;

Kitchen M. ;

Lishchuk A. ;

Smith D. .

Biosensors and Bioelectronics: X, 2024, 18

[23] A Novel Approach for Designing Electrochemical Aptamer-Based Biosensor for Ultrasensitive Detection of Zearalenone as a Prevalent Estrogenic Mycotoxin [J].

Hassani, Shokoufeh ;

Maghsoudi, Armin Salek ;

Akmal, Milad Rezaei ;

Shoeibi, Shahram ;

Ghadipasha, Fatemeh ;

Mousavi, Taraneh ;

Ganjali, Mohammad Reza ;

Hosseini, Rohollah ;

Abdollahi, Mohammad .

CURRENT MEDICINAL CHEMISTRY, 2022, 29 (37) :5881-5894

[24] A TaqMan-based real-time PCR for detection and quantification of newly identified novel pigeon adenovirus [J].

Wan, Chunhe ;

Chen, Cuiteng ;

Cheng, Longfei ;

Fu, Guanghua ;

Shi, Shaohua ;

Liu, Rongchang ;

Chen, Hongmei ;

Fu, Qiuling ;

Huang, Yu .

JOURNAL OF VIROLOGICAL METHODS, 2018, 261 :6-9

[25] A novel colorimetric sandwich aptasensor based on an indirect competitive enzyme-free method for ultrasensitive detection of chloramphenicol [J].

Abnous, Khalil ;

Danesh, Noor Mohammad ;

Ramezani, Mohammad ;

Emrani, Ahmad Sarreshtehdar ;

Taghdisi, Seyed Mohammad .

BIOSENSORS & BIOELECTRONICS, 2016, 78 :80-86

[26] Novel real-time cell analysis platform for the dynamic monitoring of ionizing radiation effects on human tumor cell lines and primary fibroblasts [J].

Man, Imola ;

Szebeni, Gabor J. ;

Plangar, Imola ;

Szabo, Emilia R. ;

Tokes, Tuende ;

Szabo, Zoltan ;

Nagy, Zoltan ;

Fekete, Gabor ;

Fajka-Boja, Roberta ;

Puskas, Laszlo G. ;

Hideghety, Katalin ;

Hackler, Laszlo, Jr. .

MOLECULAR MEDICINE REPORTS, 2015, 12 (03) :4610-4619

[27] Real-time, ultrasensitive, and accurate dual detection of Escherichia coli O157 and Listeria monocytogenes using a field-effect transistor biosensor functionalized with aptamer groups [J].

Cao, Xiaoling ;

Liu, Daohe ;

Shi, Ruiyuan ;

Li, Tingxian ;

Fang, Xiang ;

Feng, Xiaoxuan ;

Li, Pengzhen ;

Zhang, Yuhan ;

Xiao, Mengmeng ;

Wang, Li .

CHEMICAL ENGINEERING JOURNAL, 2025, 509

[28] Real-time monitoring of DNA immobilization and detection of DNA polymerase activity by a microfluidic nanoplasmonic platform [J].

Roether, Johanna ;

Chu, Kang-Yu ;

Willenbacher, Norbert ;

Shen, Amy Q. ;

Bhalla, Nikhil .

BIOSENSORS & BIOELECTRONICS, 2019, 142

[29] Evaluation of the automated Becton Dickinson MAX real-time PCR platform for detection of Pneumocystis jirovecii [J].

Chien, Jung-Yien ;

Liu, Chia-Jung ;

Chuang, Pei-Chien ;

Lee, Tai-Fen ;

Huang, Yu-Tsung ;

Liao, Chun-Hsing ;

Hung, Chien-Ching ;

Sheng, Wan-Huei ;

Yu, Chong-Jen ;

Hsueh, Po-Ren .

FUTURE MICROBIOLOGY, 2017, 12 (01) :29-37

[30] Multiplex TaqMan real-time PCR platform for detection of Neisseria gonorrhoeae with decreased susceptibility to ceftriaxone [J].

Zhao, Lihong ;

Liu, Aihua ;

Li, Ruiying ;

Zhao, Shuping .

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2019, 93 (04) :299-304

← 1 2 3 4 5 →