4-HYDROXY-2-QUINOLONES 148. SYNTHESIS AND ANTI-TUBERCULAR ACTIVITY OF 1-HYDROXY-3-OXO-6,7-DIHYDRO-3H,5H-PYRIDO[3,2,1-ij]QUINOLINE-2-CARBOXYLIC ACID N-R-AMIDES

被引：7
|
作者：
Ukrainets, I. V. [1 ]
Tkach, A. A. [1 ]
Grinevich, L. A. [1 ]
机构：
[1] Natl Univ Pharm, UA-61002 Kharkov, Ukraine
来源：
CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2008年 / 44卷 / 08期
关键词：
hetarylamides; 4-hydroxy-2-oxoquinoline-3-carboxylic acids; amidation; antitubercular activity; X-ray structural analysis;
D O I：
10.1007/s10593-008-0139-9
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An improved method for the preparation of ethyl 1-hydroxy-3-oxo-6,7-dihydro-3H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylate has been proposed and a series of hetarylamides has been synthesized from it. A comparative analysis has been carried out of the antitubercular activities of the synthesized compounds with the active structural analogs 4-hydroxy-2-oxo-1,2-dihydroquinoline-3 and 1-hydroxy-3-oxo-5,6-dihydro-3H-pyrrolo[3,2,1-ij]quinoline-2-carboxamides studied before.
引用
收藏
页码：956 / 966
页数：11
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