Tryptophan-kynurenine and lipid related metabolites as blood biomarkers for first-episode drug-naive patients with major depressive disorder: An exploratory pilot case-control study

被引：48

作者：

Kuwano, Nobuki ^{[1
]}

Kato, Takahiro A. ^{[1
]}

Setoyama, Daiki ^{[2
]}

Sato-Kasai, Mina ^{[1
]}

Shimokawa, Norihiro ^{[1
]}

Hayakawa, Kohei ^{[1
]}

Ohgidani, Masahiro ^{[1
]}

Sagata, Noriaki ^{[1
]}

Kubo, Hiroaki ^{[1
]}

Kishimoto, Junji ^{[3
]}

Kang, Dongchon ^{[2
]}

Kanba, Shigenob ^{[1
]}

机构：

[1] Kyushu Univ, Grad Sch Med Sci, Dept Neuropsychiat, Higashi Ku, Maidashi 3-1-1, Fukuoka 8128582, Japan

[2] Kyushu Univ, Grad Sch Med Sci, Dept Clin Chem & Lab Med, Higashi Ku, Maidashi 3-1-1, Fukuoka 8128582, Japan

[3] Kyushu Univ, Dept Res & Dev Next Generat Med, Fac Med Sci, Higashi Ku, Maidashi 3-1-1, Fukuoka 8128582, Japan

来源：

JOURNAL OF AFFECTIVE DISORDERS | 2018年 / 231卷

基金：

日本学术振兴会;

关键词：

First-episode drug-naive major depressive disorder; Blood biomarkers; Tryptophan-kynurenine metabolites; High density lipoprotein-cholesterol; Cholesteryl esters; INDUCED MICROGLIAL ACTIVATION; C-REACTIVE PROTEIN; OXIDATIVE STRESS; NITROSATIVE STRESS; CHOLESTERYL ESTERS; PLASMA KYNURENINE; AMINO-ACIDS; BRAIN; DEPLETION; PATHWAY;

D O I：

10.1016/j.jad.2018.01.014

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Early intervention in depression has been critical to prevent its negative impact including suicide. Recent blood biomarker studies for major depressive disorder (MDD) have suggested that tryptophan-kynurenine and lipid related metabolites are involved in the pathophysiology of MDD. However, there have been limited studies investigating these blood biomarkers in first-episode drug-naive MDD, which are particularly important for early intervention in depression. Methods: As an exploratory pilot case-control study, we examined the above blood biomarkers, and analyzed how these biomarkers are associated with clinical variables in first-episode drug-naive MDD patients, based on metabolome/lipidome analysis. Results: Plasma tryptophan and kynurenine levels were significantly lower in MDD group (N = 15) compared to healthy controls (HC) group (N = 19), and plasma tryptophan was the significant biomarker to identify MDD group (area under the curve = 0.740). Lower serum high density lipoprotein-cholesterol (HDL-C) was the predictive biomarker for severity of depression in MDD group (R-2 = 0.444). Interestingly, depressive symptoms were variously correlated with plasma tryptophan-kynurenine and lipid related metabolites. Moreover, plasma tryptophan-kynurenine metabolites and cholesteryl esters (CEs) were significantly correlated in MDD group, but not in HC group. Limitations: This study had small sample size, and we did not use the multiple test correction. Conclusions: This is the first study to suggest that not only tryptophan-kynurenine metabolites but also HDL-C and CEs are important blood biomarkers for first-episode drug-naive MDD patients. The present study sheds new light on early intervention in clinical practice in depression, and further clinical studies especially large-scale prospective studies are warranted.

引用

页码：74 / 82

页数：9

共 100 条

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