Incorporating prognostic imaging biomarkers into clinical practice

被引:10
作者
Law, W. Phillip [1 ,2 ]
Miles, Kenneth A. [1 ,3 ]
机构
[1] Princess Alexandra Hosp, Dept Med Imaging, Brisbane, Qld 4102, Australia
[2] Univ Queensland, Southern Clin Sch, Sch Med, Brisbane, Qld, Australia
[3] UCL, Inst Nucl Med, London WC1E 6BT, England
关键词
Prognostic; hazard ratio; imaging biomarker; cancer; clinical practice; POSITRON-EMISSION-TOMOGRAPHY; METABOLIC TUMOR VOLUME; SQUAMOUS-CELL CARCINOMA; TOTAL LESION GLYCOLYSIS; DISEASE-FREE SURVIVAL; NON-HODGKINS-LYMPHOMA; CT TEXTURE ANALYSIS; F-18-FDG PET; COLORECTAL-CANCER; C-11-METHIONINE PET;
D O I
10.1102/1470-7330.2013.9003
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
A prognostic imaging biomarker can be defined as an imaging characteristic that is objectively measurable and provides information on the likely outcome of the cancer disease in an untreated individual and should be distinguished from predictive imaging biomarkers and imaging markers of response. A range of tumour characteristics of potential prognostic value can be measured using a variety imaging modalities. However, none has currently been adopted into routine clinical practice. This article considers key examples of emerging prognostic imaging biomarkers and proposes an evaluation framework that aims to demonstrate clinical efficacy and so support their introduction into the clinical arena. With appropriate validation within an established evaluation framework, prognostic imaging biomarkers have the potential to contribute to individualized cancer care, in some cases reducing the financial burden of expensive cancer treatments by facilitating their more rational use.
引用
收藏
页码:332 / 341
页数:10
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