Roles of NF-κB in Cancer and Inflammatory Diseases and Their Therapeutic Approaches

被引：475
|
作者：
Park, Mi Hee
Hong, Jin Tae [1 ]
机构：
[1] Chungbuk Natl Univ, Coll Pharm, 194-31,Osongsaengmyeong 1 Ro, Cheongwon Gun 28160, Chungbuk, South Korea
来源：
CELLS | 2016年 / 5卷 / 02期
基金：
新加坡国家研究基金会;
关键词：
NF-kappa B; canonical pathway; non-canonical pathway; cancer; inflammatory disease; therapeutic approaches; NECROSIS-FACTOR-ALPHA; CYCLIN D1 EXPRESSION; TRANSCRIPTION FACTORS; IKK-ALPHA; SESQUITERPENE LACTONES; SIGNALING PATHWAYS; SODIUM-SALICYLATE; INDUCED APOPTOSIS; NF-KAPPA-B2; P100; GENE-EXPRESSION;
D O I：
10.3390/cells5020015
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Nuclear factor-kappa B (NF-kappa B) is a transcription factor that plays a crucial role in various biological processes, including immune response, inflammation, cell growth and survival, and development. NF-kappa B is critical for human health, and aberrant NF-kappa B activation contributes to development of various autoimmune, inflammatory and malignant disorders including rheumatoid arthritis, atherosclerosis, inflammatory bowel diseases, multiple sclerosis and malignant tumors. Thus, inhibiting NF-kappa B signaling has potential therapeutic applications in cancer and inflammatory diseases.
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收藏
页数：13
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