Roles of NF-κB in Cancer and Inflammatory Diseases and Their Therapeutic Approaches

被引：487

作者：

Park, Mi Hee

Hong, Jin Tae ^{[1
]}

机构：

[1] Chungbuk Natl Univ, Coll Pharm, 194-31,Osongsaengmyeong 1 Ro, Cheongwon Gun 28160, Chungbuk, South Korea

来源：

CELLS | 2016年 / 5卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

NF-kappa B; canonical pathway; non-canonical pathway; cancer; inflammatory disease; therapeutic approaches; NECROSIS-FACTOR-ALPHA; CYCLIN D1 EXPRESSION; TRANSCRIPTION FACTORS; IKK-ALPHA; SESQUITERPENE LACTONES; SIGNALING PATHWAYS; SODIUM-SALICYLATE; INDUCED APOPTOSIS; NF-KAPPA-B2; P100; GENE-EXPRESSION;

D O I：

10.3390/cells5020015

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Nuclear factor-kappa B (NF-kappa B) is a transcription factor that plays a crucial role in various biological processes, including immune response, inflammation, cell growth and survival, and development. NF-kappa B is critical for human health, and aberrant NF-kappa B activation contributes to development of various autoimmune, inflammatory and malignant disorders including rheumatoid arthritis, atherosclerosis, inflammatory bowel diseases, multiple sclerosis and malignant tumors. Thus, inhibiting NF-kappa B signaling has potential therapeutic applications in cancer and inflammatory diseases.

引用

页数：13

共 115 条

[1] Oral administration of the anti-inflammatory substance triflusal results in the downregulation of constitutive transcription factor NF-κB in the postnatal rat brain [J].