Primary anti-phospholipid syndrome: any role for serum complement levels in predicting pregnancy complications?

被引：35

作者：

Reggia, Rossella ^{[1
,2
]}

Ziglioli, Tamara ^{[1
,2
]}

Andreoli, Laura ^{[1
,2
]}

Bellisai, Francesca ^{[3
]}

Iuliano, Annamaria ^{[3
]}

Gerosa, Maria ^{[4
]}

Ramoni, Veronique ^{[5
]}

Tani, Chiara ^{[6
]}

Brucato, Antonio ^{[7
]}

Galeazzi, Mauro ^{[3
]}

Mosca, Marta ^{[6
]}

Caporali, Roberto ^{[5
]}

Meroni, Pier Luigi ^{[4
]}

Tincani, Angela ^{[1
,2
]}

机构：

[1] Spedali Civil Brescia, I-25123 Brescia, Italy

[2] Univ Brescia, I-25123 Brescia, Italy

[3] Policlin Le Scotte, Siena, Italy

[4] Univ Milan, Ist G Pini, Milan, Italy

[5] Policlin San Matteo Fdn, Pavia, Italy

[6] Univ Pisa, Dept Internal Med, Rheumatol Unit, I-56100 Pisa, Italy

[7] Osped Riuniti Bergamo, I-24100 Bergamo, Italy

来源：

RHEUMATOLOGY | 2012年 / 51卷 / 12期

关键词：

obstetric APS; complement; aPL; pregnancy-specific normality range; pre-eclampsia; ACTIVATION; MODEL;

D O I：

10.1093/rheumatology/kes225

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. To evaluate the association between serum complement levels (C3 and C4) and obstetric complications. Methods. Fifty-seven pregnancies in primary APS (PAPS) patients were compared with 49 pregnancies in patients with UCTD and SS. A group of 175 healthy pregnant women were studied to calculate a normality range for C3 and C4 during pregnancy. Such a range was applied to define hypocomplementaemia in PAPS and UCTD/SS. Results. Both groups of patients (PAPS and UCTD/SS) showed significantly lower levels of C3 and C4 in each trimester as compared with healthy women; conversely, no significant difference was found between PAPS and UCTD/SS. Comparing PAPS pregnancies with and without complications, no difference was found in the prevalence of low C3 or low C4. Conclusion. No association was found between hypocomplementaemia and obstetric complications in PAPS. However, both cases of pre-eclampsia were characterized by low C3 throughout pregnancy. There is evidence that the complement system is a contributor to the mechanisms of aPL-mediated damage, but its predictive role on the final pregnancy outcome does not seem to be of major impact.

引用

页码：2186 / 2190

页数：5

共 19 条

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