Modulation of parathyroid cell function by calcium ion in health and uremia

被引：8
作者：
Akizawa, T
Fukagawa, M
机构：
[1] Showa Univ, Fujigaoka Hosp, Div Nephrol, Aoba Ku, Yokohama, Kanagawa 2278501, Japan
[2] Tokyo Teishin Hosp, Tokyo, Japan
来源：
AMERICAN JOURNAL OF THE MEDICAL SCIENCES | 1999年 / 317卷 / 06期
关键词：
calcium; parathyroid hormone (PTH); sigmoidal curve; calcium-sensing receptor;
D O I：
10.1097/00000441-199906000-00002
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Extracellular calcium ion concentration is the major determinant of parathyroid hormone (PTH) secretion from parathyroid cells. In dialysis patients with secondary hyperparathyroidism, higher calcium concentration is needed to suppress PTH secretion as demonstrated by the PTH-calcium curve. Such abnormal sensitivity to extracellular calcium ion has been recently explained by the decrease in number of calcium-sensing receptors, especially on cells in nodular hyperplasia, which is the advanced type of parathyroid hyperplasia, in uremia, Modulation of the sensitivity of parathyroid cells to calcium has become partly possible through the use. of newly developed calcimimetics.
引用
收藏
页码：358 / 362
页数：5
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