Hepatitis B in pregnancy

被引：96

作者：

Borgia, Guglielmo ^{[1
]}

Carleo, Maria Aurora ^{[1
]}

Gaeta, Giovanni Battista ^{[2
]}

Gentile, Ivan ^{[1
]}

机构：

[1] Univ Naples Federico II, Dept Publ Med & Social Secur, Infect Dis Sect, I-80131 Naples, Italy

[2] Univ Naples 2, Dept Internal Med, Infect Dis Sect, I-80131 Naples, Italy

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2012年 / 18卷 / 34期

关键词：

Hepatitis B virus; Pregnancy; Therapy; Tenofovir; Lamivudine; Telbivudine; Entecavir; Breastfeeding; Elective caesarean section; PREVENT PERINATAL TRANSMISSION; TO-CHILD TRANSMISSION; VIRUS INFECTION; E-ANTIGEN; TRANSPLACENTAL TRANSMISSION; VERTICAL TRANSMISSION; DOUBLE-BLIND; LAMIVUDINE; TENOFOVIR; MECHANISM;

D O I：

10.3748/wjg.v18.i34.4677

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Chronic hepatitis B virus (HBV) infection affects about 350 million individuals worldwide. Management of HBV infection in pregnancy is difficult because of several peculiar and somewhat controversial aspects. The aim of the present review is to provide a tool that may help physicians to correctly manage HBV infection in pregnancy. This review focuses on (1) the effect of pregnancy on HBV infection and of HBV infection on pregnancy; (2) the potential viral transmission from mother to newborn despite at-birth prophylaxis with immunoglobulin and vaccine; (3) possible prevention of mother-to-child transmission through antiviral drugs, the type of antiviral drug to use considering their efficacy and potential teratogenic effect, and the timing of their administration and discontinuation; and (4) the evidence for the use of elective caesarean section vs vaginal delivery and the possibility of breastfeeding. (c) 2012 Baishideng. All rights reserved.

引用

页码：4677 / 4683

页数：7

共 30 条

[1] Relationship of hepatitis B virus infection of placental barrier and hepatitis B virus intra-uterine transmission mechanism [J].