Autologous nanofat transplantation accelerates foot wound healing in diabetic rats

被引：26

作者：

Chen, Li ^{[1
]}

Wang, Zheng-Cai ^{[1
]}

Ma, Jing-Jing ^{[1
]}

Sun, Wen-Jia ^{[1
]}

Wang, Shao-Wen ^{[2
]}

Gu, Zi-Chun ^{[1
]}

Yang, Xuan ^{[1
]}

机构：

[1] Zhejiang Univ, Coll Med, Sir Run Run Shaw Hosp, Dept Plast & Reconstruct Surg, Hangzhou 310016, Peoples R China

[2] Zhejiang Univ, Sir Run Run Shaw Hosp, Dept Gen Surg, Coll Med, Hangzhou 310016, Peoples R China

来源：

REGENERATIVE MEDICINE | 2019年 / 14卷 / 03期

关键词：

adipose-derived stem cells; angiogenesis; autologous transplantation; chronic wound healing; diabetic rats; extracellular matrix; nanofat; re-epithelialization; therapy; ADIPOSE-TISSUE; STEM-CELLS; MATRIX; PROLIFERATION; SECRETION; MIGRATION; THERAPY; MODEL; RICH; GEL;

D O I：

10.2217/rme-2018-0169

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Aim: This study explored the effects of local transplantation of autologous nanofat in the treatment of rats with diabetic foot wounds. Materials & methods: Nanofat was transplanted into the left foot wound of diabetic rats. Phosphate-buffered saline injection in the right served as control. We measured wound size, the extent of epithelization, microvessel density and the expression levels of cytokines at six different time-points postoperation. Results: Comparedwith the control feet, nanofat-treated feet had significantly smaller wound areas at 7 and 9 days after grafting and showed better re-epithelialization, a greater number of microvessels and higher levels of angiogenic factor expression. Conclusion: This research shows that autologous nanofat transplantation can promote diabetic foot wound healing in rats.

引用

页码：231 / 241

页数：11

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