Smad-mediated regulation of microRNA biosynthesis

被引：99
作者：
Blahna, Matthew T. [1 ]
Hata, Akiko [1 ]
机构：
[1] Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94158 USA
来源：
FEBS LETTERS | 2012年 / 586卷 / 14期
关键词：
microRNA; Smad; TGF-beta; BMP; Drosha; Dicer; Argonaute; GROWTH-FACTOR-BETA; SMOOTH-MUSCLE-CELLS; P68 RNA HELICASE; POSTTRANSCRIPTIONAL REGULATION; TRANSCRIPTIONAL ACTIVATION; SIGNALING PATHWAYS; BINDING-PROTEIN; RENAL FIBROSIS; MESSENGER-RNAS; POLYMERASE-II;
D O I：
10.1016/j.febslet.2012.01.041
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
microRNAs (miRNAs) are small non-coding RNAs conserved in metazoans. Depletion of miRNAs results in embryonic lethality, suggesting they are essential for embryogenesis. Similarly, pathways induced by growth factors of the transforming growth factor beta (TGF-beta) superfamily control cell growth, differentiation, and development. Recently Smad proteins, the signal transducers of the TGF-beta pathway, were found to regulate miRNA expression, which, in turn, affects expression of numerous proteins. Smads modulate miRNA expression through both transcriptional and post-transcriptional mechanisms illustrating the complexity of gene regulation by TGF-beta. In this chapter we summarize the current knowledge of mechanisms underlying Smad-mediated regulation of miRNA biogenesis. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：1906 / 1912
页数：7
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