Lipase enzymatic microreactor in polysaccharide hydrogel: structure and properties

被引：15
作者：
Bogdanova, L. R. [1 ]
Rogov, A. M. [2 ]
Zueva, O. S. [3 ]
Zuev, Yu F. [1 ,2 ,3 ]
机构：
[1] Russian Acad Sci, Kazan Sci Ctr, Kazan Inst Biochem & Biophys, Fed Res Ctr, 2-13 Ul Lobachevskogo, Kazan 420111, Russia
[2] Kazan Volga Reg Fed Univ, 18 Ul Kremlevskaya, Kazan 420018, Russia
[3] Kazan State Power Engn Univ, 51 Ul Krasnoselskaya, Kazan 420066, Russia
来源：
RUSSIAN CHEMICAL BULLETIN | 2019年 / 68卷 / 02期
基金：
俄罗斯科学基金会;
关键词：
polysaccharide hydrogel; lipase; immobilization; enzymatic catalysis; INTERFACIAL ACTIVATION; KINETICS;
D O I：
10.1007/s11172-019-2399-1
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An enzymatic microreactor was designed on the basis of sodium alginate hydrogel containing a lipolytic enzyme (Candida rugosa lipase) in the polymer matrix pores. The functional properties of lipase were characterized in polysaccharide hydrogel of different concentrations. The polysaccharide hydrogel matrix was shown to act as a microreactor, where the enzyme retains activity during numerous catalytic cycles and allows designing long-acting drug systems of enzymatic nature.
引用
收藏
页码：400 / 404
页数：5
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