In vitro activities of pyronaridine, alone and in combination with other antimalarial drugs, against Plasmodium falciparum

被引：39

作者：

Ringwald, P ^{[1
]}

Eboumbou, ECM ^{[1
]}

Bickii, J ^{[1
]}

Basco, LK ^{[1
]}

机构：

[1] OCEAC, Lab Associe Francophone 302, Inst Rech Dev, Lab Rech Paludisme, Yaounde, Cameroon

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1999年 / 43卷 / 06期

关键词：

D O I：

10.1128/AAC.43.6.1525

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The in vitro activities of pyronaridine, alone and in combination with established antimalarial drugs, were assessed by isotopic microtest. Pyronaridine was highly active against all Cameroonian isolates. ii positive correlation was observed bet between the response to pyronaridine and that to chloroquine. Drug combination studies shelved synergy between pyronaridine and primaquine, additive effects with 4-aminoquinolines, and weak antagonism with dihydroartemisinin, antifolates, or amino alcohols.

引用

页码：1525 / 1527

页数：3

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