Monte Carlo Simulation-Guided Design of a Thorium-Based Metal-Organic Framework for Efficient Radiotherapy-Radiodynamic Therapy

被引：30

作者：

Xu, Ziwan ^{[1
]}

Luo, Taokun ^{[1
]}

Mao, Jianming ^{[1
]}

McCleary, Caroline ^{[1
]}

Yuan, Eric ^{[1
]}

Lin, Wenbin ^{[1
,2
,3
]}

机构：

[1] Univ Chicago, Dept Chem, 5735 S Ellis Ave, Chicago, IL 60637 USA

[2] Univ Chicago, Dept Radiat & Cellular Oncol, Chicago, IL 60637 USA

[3] Univ Chicago, Ludwig Ctr Metastasis Res, Chicago, IL 60637 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2022年 / 61卷 / 46期

关键词：

Metal-Organic Framework; Monte Carlo Simulation; Radiodynamic Therapy; Radiotherapy; GOLD NANOPARTICLES; RADIATION-THERAPY;

D O I：

10.1002/anie.202208685

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

High-Z metal-based nanoscale metal-organic frameworks (nMOFs) with photosensitizing ligands can enhance radiation damage to tumors via a unique radiotherapy-radiodynamic therapy (RT-RDT) process. Here we report Monte Carlo (MC) simulation-guided design of a Th-based nMOF built from Th-6-oxo secondary building units and 5,15-di(p-benzoato)porphyrin (DBP) ligands, Th-DBP, for enhanced RT-RDT. MC simulations revealed that the Th-lattice outperformed the Hf-lattice in radiation dose enhancement owing to its higher mass attenuation coefficient. Upon X-ray or gamma-ray radiation, Th-DBP enhanced energy deposition, generated more reactive oxygen species, and induced significantly higher cytotoxicity to cancer cells over the previously reported Hf-DBP nMOF. With low-dose X-ray irradiation, Th-DBP suppressed tumor growth by 88 % in a colon cancer and 97 % in a pancreatic cancer mouse model.

引用

页数：6

共 5 条

[1] Digitonin-Loaded Nanoscale Metal-Organic Framework for Mitochondria-Targeted Radiotherapy-Radiodynamic Therapy and Disulfidptosis
Zhen, Wenyao
Fan, Yingjie
Germanas, Tomas
Tillman, Langston
Li, Jinhong
Blenko, Abigail L.
Weichselbaum, Ralph R.
Lin, Wenbin
ADVANCED MATERIALS, 2024,
[2] Oxygen-Evolving Radiotherapy-Radiodynamic Therapy Synergized with NO Gas Therapy by Cerium-Based Rare-Earth Metal-Porphyrin Framework
Lin, Jinyan
He, Yueyang
Li, Yang
Chen, Jianwu
Liu, Xiaolong
SMALL, 2024, 20 (36)
[3] Low-dose X-ray radiotherapy-radiodynamic therapy via nanoscale metal-organic frameworks enhances checkpoint blockade immunotherapy
Lu, Kuangda
He, Chunbai
Guo, Nining
Chan, Christina
Ni, Kaiyuan
Lan, Guangxu
Tang, Haidong
Pelizzari, Charles
Fu, Yang-Xin
Spiotto, Michael T.
Weichselbaum, Ralph R.
Lin, Wenbin
NATURE BIOMEDICAL ENGINEERING, 2018, 2 (08): : 600 - +
[4] Monte Carlo Simulations Reveal New Design Principles for Efficient Nanoradiosensitizers Based on Nanoscale Metal-Organic Frameworks
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Ni, Kaiyuan
Mao, Jianming
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ADVANCED MATERIALS, 2021, 33 (40)
[5] Designing Bimetallic Metal-Organic Framework-Based Heterojunction Radiosensitizer for Enhanced Radiodynamic Therapy and Immunotherapy
Xiong, Zushuang
Yang, Mingqi
Liu, Peixin
Tang, Zhiying
Yang, Yu
Zhan, Meixiao
Chen, Tianfeng
Li, Xiaoling
Lu, Ligong
ADVANCED FUNCTIONAL MATERIALS, 2024, 34 (11)

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