Monte Carlo Simulation-Guided Design of a Thorium-Based Metal-Organic Framework for Efficient Radiotherapy-Radiodynamic Therapy

被引：36

作者：

Xu, Ziwan ^{[1
]}

Luo, Taokun ^{[1
]}

Mao, Jianming ^{[1
]}

McCleary, Caroline ^{[1
]}

Yuan, Eric ^{[1
]}

Lin, Wenbin ^{[1
,2
,3
]}

机构：

[1] Univ Chicago, Dept Chem, 5735 S Ellis Ave, Chicago, IL 60637 USA

[2] Univ Chicago, Dept Radiat & Cellular Oncol, Chicago, IL 60637 USA

[3] Univ Chicago, Ludwig Ctr Metastasis Res, Chicago, IL 60637 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2022年 / 61卷 / 46期

关键词：

Metal-Organic Framework; Monte Carlo Simulation; Radiodynamic Therapy; Radiotherapy; GOLD NANOPARTICLES; RADIATION-THERAPY;

D O I：

10.1002/anie.202208685

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

High-Z metal-based nanoscale metal-organic frameworks (nMOFs) with photosensitizing ligands can enhance radiation damage to tumors via a unique radiotherapy-radiodynamic therapy (RT-RDT) process. Here we report Monte Carlo (MC) simulation-guided design of a Th-based nMOF built from Th-6-oxo secondary building units and 5,15-di(p-benzoato)porphyrin (DBP) ligands, Th-DBP, for enhanced RT-RDT. MC simulations revealed that the Th-lattice outperformed the Hf-lattice in radiation dose enhancement owing to its higher mass attenuation coefficient. Upon X-ray or gamma-ray radiation, Th-DBP enhanced energy deposition, generated more reactive oxygen species, and induced significantly higher cytotoxicity to cancer cells over the previously reported Hf-DBP nMOF. With low-dose X-ray irradiation, Th-DBP suppressed tumor growth by 88 % in a colon cancer and 97 % in a pancreatic cancer mouse model.

引用

页数：6

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