An active cognitive lifestyle as a potential neuroprotective factor in Huntington's disease

被引：18

作者：

Garcia-Gorro, Clara ^{[1
,2
]}

Garau-Rolandi, Maria ^{[3
]}

Escrichs, Anira ^{[1
]}

Rodriguez-Dechicha, Nadia ^{[3
]}

Vaquer, Irene ^{[3
]}

Subira, Susana ^{[3
,4
]}

Calopa, Matilde ^{[5
]}

Martinez-Horta, Saul ^{[6
,7
]}

Perez-Perez, Jesus ^{[6
,7
]}

Kulisevsky, Jaime ^{[6
,7
,8
]}

Munoz, Esteban ^{[9
,10
,11
]}

Santacruz, Pilar ^{[9
]}

Ruiz-Idiago, Jesus ^{[12
]}

Mareca, Celia ^{[12
]}

de Diego-Balaguer, Ruth ^{[1
,2
,13
,14
]}

Camara, Estela ^{[1
]}

机构：

[1] IDIBELL Inst Invest Biomed Bellvitge, Neurosci Program, Cognit & Brain Plast Unit, Barcelona, Spain

[2] Univ Barcelona, Dept Cognit Dev & Educ Psychol, Barcelona, Spain

[3] Hosp Duran i Reynals, Hestia Duran i Reynals, Barcelona, Spain

[4] Univ Autonoma Barcelona, Dept Clin & Hlth Psychol, Barcelona, Spain

[5] Hosp Univ Bellvitge, Movement Disorders Unit, Neurol Serv, Barcelona, Spain

[6] Hosp Santa Creu & Sant Pau, Biomed Res Inst St Pau IIB St Pau, Dept Neurol, Movement Disorders Unit, Barcelona, Spain

[7] Carlos III Inst, CIBERNED Ctr Networked Biomed Res Neurodegenerat, Madrid, Spain

[8] Univ Autonoma Barcelona, Barcelona, Spain

[9] Hosp Clin Barcelona, Movement Disorders Unit, Neurol Serv, Barcelona, Spain

[10] IDIBAPS Inst Invest Biomed August Pi i Sunyer, Barcelona, Spain

[11] Univ Barcelona, Fac Med, Barcelona, Spain

[12] Hosp Mare Deu Merce, Barcelona, Spain

[13] Univ Barcelona, Inst Neurosci, Barcelona, Spain

[14] ICREA Catalan Inst Res & Adv Studies, Barcelona, Spain

来源：

NEUROPSYCHOLOGIA | 2019年 / 122卷

关键词：

Cognitive engagement; Neurodegeneration; Huntington's disease; Executive functions; Resting-state fMRI; RESTING-STATE CONNECTIVITY; TRANSGENIC MOUSE MODEL; CAG-REPEAT LENGTH; AGE-OF-ONSET; BRAIN RESERVE; ALZHEIMERS; COMPENSATION; IMPAIRMENT; EDUCATION; IMPACT;

D O I：

10.1016/j.neuropsychologia.2018.10.017

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

A cognitive stimulating lifestyle has been observed to confer cognitive benefits in multiple neurodegenerative diseases. However, the underlying neurobiological basis of this phenomenon remains unclear. Huntington's disease can provide a suitable model to study the effects and neural mechanisms of cognitive engagement in neurodegeneration. In this study, we investigate the effect of lifestyle factors such as education, occupation and engagement in cognitive activities in Huntington's disease gene carriers on cognitive performance and age of onset as well as the underlying neural changes sustaining these effects, measured by magnetic resonance imaging. Specifically, we analyzed both gray matter volume and the strength of connectivity of the executive control resting-state network. High levels of cognitive engagement were significantly associated with more preserved executive functions, a delay in the appearance of symptoms, reduced volume loss of the left precuneus and the bilateral caudate and a modulation of connectivity strength of anterior cingulate cortex and left angular gyrus with the executive control network. These findings suggest that a cognitively stimulating lifestyle may promote brain maintenance by modulating the executive control resting-state network and conferring protection against neurodegeneration, which results in a delayed onset of symptoms and improved performance in executive functions.

引用

页码：116 / 124

页数：9

共 88 条

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