Therapeutic effects of androgens for cachexia

被引：6

作者：

Giovanelli, Luca ^{[1
,2
,3
]}

Quinton, Richard ^{[3
,4
,5
]}

机构：

[1] Univ Milan, Dept Med Biotechnol & Translat Med, I-20100 Milan, Italy

[2] IRCCS Ist Auxol Italiano, Dept Endocrine & Metab Med, I-20100 Milan, Italy

[3] Newcastle upon Tyne Hosp, Dept Endocrinol Diabet & Metab, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England

[4] Newcastle Univ, Translat & Clin Res Inst, Newcastle Upon Tyne NE1 3BZ, Tyne & Wear, England

[5] Royal Victoria firmary, Endocrine Unit, Leazes Wing Level 6,Queen Victoria Rd, Newcastle Upon Tyne NE1 4LP, England

来源：

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM | 2022年 / 36卷 / 05期

关键词：

cachexia; muscle wasting; HIV; androgens; testosterone; selective androgen receptor modulators; CHRONIC HEART-FAILURE; CELL LUNG-CANCER; QUALITY-OF-LIFE; LEAN BODY-MASS; PLACEBO-CONTROLLED TRIAL; SKELETAL-MUSCLE PERFORMANCE; HUMAN GROWTH-HORMONE; DOUBLE-BLIND; TESTOSTERONE THERAPY; PHYSICAL FUNCTION;

D O I：

10.1016/j.beem.2021.101598

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cachexia is a complex wasting syndrome, accompanying a variety of end-stage chronic diseases, such as cancer, heart failure and human immunodeficiency virus (HIV) infection/acquired immunodeficiency syndrome (AIDS). It significantly affects patients' quality of life and survival. Multiple therapeutic approaches have been studied over time. However, despite promising results, no drug has been approved to date. In this review, we examine and discuss the available data on the therapeutic effects of androgens and selective androgen receptor modulators (SARMs) for cachexia.(c) 2021 Elsevier Ltd. All rights reserved.

引用

页数：17

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