共 50 条
- [31] Phase I study of the pharmacokinetics and tolerability of everolimus in Chinese patients with advanced solid tumors.JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (15)Xu, B.论文数: 0 引用数: 0 h-index: 0机构: Chinese Acad Med Sci, Canc Hosp, Beijing 100730, Peoples R ChinaShen, L.论文数: 0 引用数: 0 h-index: 0机构: Chinese Acad Med Sci, Canc Hosp, Beijing 100730, Peoples R ChinaYe, D.论文数: 0 引用数: 0 h-index: 0机构: Chinese Acad Med Sci, Canc Hosp, Beijing 100730, Peoples R ChinaJappe, A.论文数: 0 引用数: 0 h-index: 0机构: Chinese Acad Med Sci, Canc Hosp, Beijing 100730, Peoples R ChinaWang, H.论文数: 0 引用数: 0 h-index: 0机构: Chinese Acad Med Sci, Canc Hosp, Beijing 100730, Peoples R ChinaYuan, R.论文数: 0 引用数: 0 h-index: 0机构: Chinese Acad Med Sci, Canc Hosp, Beijing 100730, Peoples R ChinaWu, Y.论文数: 0 引用数: 0 h-index: 0机构: Chinese Acad Med Sci, Canc Hosp, Beijing 100730, Peoples R China
- [32] A PHASE I STUDY ON CABOZANTINIB MONOTHERAPY IN PEDIATRIC PATIENTS WITH RECURRENT AND/OR REFRACTORY SOLID TUMORS (CAMEL STUDY)PEDIATRIC BLOOD & CANCER, 2022, 69Nakajima, Miho论文数: 0 引用数: 0 h-index: 0机构: Natl Canc Ctr, Dept Pediat Oncol, Tokyo, Japan Natl Canc Ctr, Dept Pediat Oncol, Tokyo, JapanTao, Kayoko论文数: 0 引用数: 0 h-index: 0机构: Natl Canc Ctr, Dept Pediat Oncol, Tokyo, Japan Natl Canc Ctr, Dept Pediat Oncol, Tokyo, Japan论文数: 引用数: h-index:机构:Ogawa, Chitose论文数: 0 引用数: 0 h-index: 0机构: Natl Canc Ctr, Dept Pediat Oncol, Tokyo, Japan Natl Canc Ctr, Dept Pediat Oncol, Tokyo, JapanArakawa, Ayumu论文数: 0 引用数: 0 h-index: 0机构: Natl Canc Ctr, Dept Pediat Oncol, Tokyo, Japan Natl Canc Ctr, Dept Pediat Oncol, Tokyo, Japan
- [33] Single-agent dose-finding cohort of a phase 1/2 study of lenvatinib (LEN) in children and adolescents with refractory or relapsed solid tumors.JOURNAL OF CLINICAL ONCOLOGY, 2017, 35Gaspar, Nathalie论文数: 0 引用数: 0 h-index: 0Melcon, Maria Soledad Gallego论文数: 0 引用数: 0 h-index: 0Venkatramani, Rajkumar论文数: 0 引用数: 0 h-index: 0Bielack, Stefan S.论文数: 0 引用数: 0 h-index: 0Casanova, Michela论文数: 0 引用数: 0 h-index: 0Locatelli, Franco论文数: 0 引用数: 0 h-index: 0Thebaud, Estelle论文数: 0 引用数: 0 h-index: 0Rigaud, Charlotte论文数: 0 引用数: 0 h-index: 0Abbou, Samuel论文数: 0 引用数: 0 h-index: 0Gambart, Marion论文数: 0 引用数: 0 h-index: 0Morland, Bruce论文数: 0 引用数: 0 h-index: 0Aerts, Isabelle论文数: 0 引用数: 0 h-index: 0Kraljevic, Silvija论文数: 0 引用数: 0 h-index: 0Li, Di论文数: 0 引用数: 0 h-index: 0Maniar, Hina论文数: 0 引用数: 0 h-index: 0Hayato, Seiichi论文数: 0 引用数: 0 h-index: 0Dutcus, Corina E.论文数: 0 引用数: 0 h-index: 0Hewson, Quentin Campbell论文数: 0 引用数: 0 h-index: 0
- [34] Phase 1 study of abemaciclib in children with recurrent and refractory solid tumors including malignant brain tumorsMOLECULAR CANCER THERAPEUTICS, 2019, 18 (12)Cash, Thomas论文数: 0 引用数: 0 h-index: 0机构: Emory Univ, Sch Med, Aflac Canc & Blood Disorders Ctr, Childrens Healthcare Atlanta, Atlanta, GA USA Emory Univ, Sch Med, Dept Pediat, Atlanta, GA USA Emory Univ, Sch Med, Aflac Canc & Blood Disorders Ctr, Childrens Healthcare Atlanta, Atlanta, GA USAAguilera, Dolly论文数: 0 引用数: 0 h-index: 0机构: Emory Univ, Sch Med, Aflac Canc & Blood Disorders Ctr, Childrens Healthcare Atlanta, Atlanta, GA USA Emory Univ, Sch Med, Dept Pediat, Atlanta, GA USA Emory Univ, Sch Med, Aflac Canc & Blood Disorders Ctr, Childrens Healthcare Atlanta, Atlanta, GA USAMacy, Margaret E.论文数: 0 引用数: 0 h-index: 0机构: Childrens Hosp Colorado, Ctr Canc & Blood Disorders, Denver, CO USA Emory Univ, Sch Med, Aflac Canc & Blood Disorders Ctr, Childrens Healthcare Atlanta, Atlanta, GA USAHoffman, Lindsey论文数: 0 引用数: 0 h-index: 0机构: Univ Arizona, Coll Med Phoenix, Ctr Canc & Blood Disorders, Phoenix Childrens Hosp, Phoenix, AZ USA Univ Arizona, Coll Med Phoenix, Dept Child Hlth, Phoenix, AZ USA Emory Univ, Sch Med, Aflac Canc & Blood Disorders Ctr, Childrens Healthcare Atlanta, Atlanta, GA USADorris, Kathleen论文数: 0 引用数: 0 h-index: 0机构: Childrens Hosp Colorado, Ctr Canc & Blood Disorders, Denver, CO USA Emory Univ, Sch Med, Aflac Canc & Blood Disorders Ctr, Childrens Healthcare Atlanta, Atlanta, GA USAMcCracken, Courtney论文数: 0 引用数: 0 h-index: 0机构: Emory Univ, Sch Med, Aflac Canc & Blood Disorders Ctr, Childrens Healthcare Atlanta, Atlanta, GA USA Emory Univ, Sch Med, Dept Pediat, Atlanta, GA USA Emory Univ, Sch Med, Aflac Canc & Blood Disorders Ctr, Childrens Healthcare Atlanta, Atlanta, GA USAHanberry, Bradley论文数: 0 引用数: 0 h-index: 0机构: Emory Univ, Sch Med, Aflac Canc & Blood Disorders Ctr, Childrens Healthcare Atlanta, Atlanta, GA USA Emory Univ, Sch Med, Dept Pediat, Atlanta, GA USA Emory Univ, Sch Med, Aflac Canc & Blood Disorders Ctr, Childrens Healthcare Atlanta, Atlanta, GA USACastellino, Robert论文数: 0 引用数: 0 h-index: 0机构: Emory Univ, Sch Med, Aflac Canc & Blood Disorders Ctr, Childrens Healthcare Atlanta, Atlanta, GA USA Emory Univ, Sch Med, Dept Pediat, Atlanta, GA USA Emory Univ, Sch Med, Aflac Canc & Blood Disorders Ctr, Childrens Healthcare Atlanta, Atlanta, GA USA论文数: 引用数: h-index:机构:Wetmore, Cynthia论文数: 0 引用数: 0 h-index: 0机构: Univ Arizona, Coll Med Phoenix, Ctr Canc & Blood Disorders, Phoenix Childrens Hosp, Phoenix, AZ USA Univ Arizona, Coll Med Phoenix, Dept Child Hlth, Phoenix, AZ USA Emory Univ, Sch Med, Aflac Canc & Blood Disorders Ctr, Childrens Healthcare Atlanta, Atlanta, GA USA
- [35] Updated Entrectinib Data in Children and Adolescents with Recurrent or Refractory Solid Tumors, Including Primary CNS TumorsPEDIATRIC BLOOD & CANCER, 2020, 67论文数: 引用数: h-index:机构:Desai, Ami论文数: 0 引用数: 0 h-index: 0机构: Univ Chicago, Med Ctr, Chicago, IL 60637 USA Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Pediat, Kyoto, JapanRobinson, Giles论文数: 0 引用数: 0 h-index: 0机构: St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USA STARTRK NG Study Grp, San Francisco, CA USA Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Pediat, Kyoto, JapanBasu, Ellen论文数: 0 引用数: 0 h-index: 0机构: Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA STARTRK NG Study Grp, San Francisco, CA USA Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Pediat, Kyoto, JapanFoster, Jennifer论文数: 0 引用数: 0 h-index: 0机构: Texas Childrens Hosp, Houston, TX 77030 USA STARTRK NG Study Grp, San Francisco, CA USA Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Pediat, Kyoto, JapanGauvain, Karen论文数: 0 引用数: 0 h-index: 0机构: Washington Univ, Sch Med, St Louis, MO USA STARTRK NG Study Grp, San Francisco, CA USA Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Pediat, Kyoto, JapanSabnis, Amit论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Francisco, Benioff Childrens Hosp, San Francisco, CA 94143 USA STARTRK NG Study Grp, San Francisco, CA USA Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Pediat, Kyoto, JapanGajjar, Amar论文数: 0 引用数: 0 h-index: 0机构: St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USA STARTRK NG Study Grp, San Francisco, CA USA Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Pediat, Kyoto, Japan
- [36] ENTRECTINIB IN RECURRENT OR REFRACTORY SOLID TUMORS INCLUDING PRIMARY CNS TUMORS: UPDATED DATA IN CHILDREN AND ADOLESCENTSNEURO-ONCOLOGY, 2020, 22 : 344 - 344Robinson, Giles论文数: 0 引用数: 0 h-index: 0机构: St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USA St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USADesai, Ami论文数: 0 引用数: 0 h-index: 0机构: Univ Chicago, Med Ctr, Chicago, IL 60637 USA St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USABasu, Ellen论文数: 0 引用数: 0 h-index: 0机构: Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USAFoster, Jennifer论文数: 0 引用数: 0 h-index: 0机构: Texas Childrens Hosp, Houston, TX 77030 USA St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USAGauvain, Karen论文数: 0 引用数: 0 h-index: 0机构: Washington Univ, Sch Med, St Louis, MO USA St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USASabnis, Amit论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Francisco, Benioff Childrens Hosp, San Francisco, CA 94143 USA St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USAShusterman, Suzanne论文数: 0 引用数: 0 h-index: 0机构: Dana Farber Canc Inst, Boston Childrens Canc & Blood Disorders Ctr, Boston, MA 02115 USA St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USAMacy, Margaret论文数: 0 引用数: 0 h-index: 0机构: Childrens Hosp Colorado, Dept Hematol Oncol & Bone Marrow Transplantat, Aurora, CO USA St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USAMease, Luke论文数: 0 引用数: 0 h-index: 0机构: Univ Utah, Huntsman Canc Inst, Primary Childrens Hosp, Salt Lake City, UT USA St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USAYoon, Janet论文数: 0 引用数: 0 h-index: 0机构: Rady Childrens Hosp, San Diego, CA USA St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USACash, Thomas论文数: 0 引用数: 0 h-index: 0机构: Emory Univ, Sch Med, Childrens Healthcare Atlanta, Aflac Canc & Blood Disorders Ctr, Atlanta, GA USA St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USAAbdelbaki, Mohamed论文数: 0 引用数: 0 h-index: 0机构: Nationwide Childrens Hosp, Columbus, OH USA St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USANazemi, Kellie论文数: 0 引用数: 0 h-index: 0机构: Oregon Hlth & Sci Univ, Doernbecher Childrens Hosp, Portland, OR 97201 USA St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USAPratilas, Christine论文数: 0 引用数: 0 h-index: 0机构: Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD USA St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USAWeiss, Brian论文数: 0 引用数: 0 h-index: 0机构: Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45229 USA St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USAChohan, Saibah论文数: 0 引用数: 0 h-index: 0机构: F Hoffmann La Roche Ltd, Mississauga, ON, Canada St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USACardenas, Alison论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA USA St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USAHutchinson, Katherine论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA USA St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USABergthold, Guillaume论文数: 0 引用数: 0 h-index: 0机构: F Hoffmann La Roche, Basel, Switzerland St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USAGajjar, Amar论文数: 0 引用数: 0 h-index: 0机构: St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USA St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USA
- [37] Phase 1/1B trial to assess the activity of entrectinib in children and adolescents with recurrent or refractory solid tumors including central nervous system (CNS) tumors.JOURNAL OF CLINICAL ONCOLOGY, 2019, 37 (15)Robinson, Giles W.论文数: 0 引用数: 0 h-index: 0机构: St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USAGajjar, Amar J.论文数: 0 引用数: 0 h-index: 0机构: St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USAGauvain, Karen Marie论文数: 0 引用数: 0 h-index: 0机构: St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USABasu, Ellen M.论文数: 0 引用数: 0 h-index: 0机构: St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USAMacy, Margaret E.论文数: 0 引用数: 0 h-index: 0机构: St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USAMaese, Luke Devon论文数: 0 引用数: 0 h-index: 0机构: St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USASabnis, Amit J.论文数: 0 引用数: 0 h-index: 0机构: St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USAFoster, Jennifer Haunani论文数: 0 引用数: 0 h-index: 0机构: St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USAShusterman, Suzanne论文数: 0 引用数: 0 h-index: 0机构: St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USAYoon, Janet论文数: 0 引用数: 0 h-index: 0机构: St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USAWeiss, Brian D.论文数: 0 引用数: 0 h-index: 0机构: St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USAAbdelbaki, Mohamed论文数: 0 引用数: 0 h-index: 0机构: St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USAFarid-Kapadia, Mufiza论文数: 0 引用数: 0 h-index: 0机构: St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USAMeneses-Lorente, Georgina论文数: 0 引用数: 0 h-index: 0机构: St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USACardenas, Alison论文数: 0 引用数: 0 h-index: 0机构: St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USAHutchinson, Katherine论文数: 0 引用数: 0 h-index: 0机构: St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USABergthold, Guillaume论文数: 0 引用数: 0 h-index: 0机构: St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USAManeval, Edna Chow论文数: 0 引用数: 0 h-index: 0机构: St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USAFox, Elizabeth论文数: 0 引用数: 0 h-index: 0机构: St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USADesai, Ami Vijay论文数: 0 引用数: 0 h-index: 0机构: St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USA
- [38] Correlative analyses of serum biomarkers and efficacy outcomes in the randomized phase II trial of lenvatinib (LEN), everolimus (EVE), or LEN plus EVE in patients with metastatic renal cell carcinomaANNALS OF ONCOLOGY, 2018, 29Lee, C-H.论文数: 0 引用数: 0 h-index: 0机构: Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USAMotzer, R. J.论文数: 0 引用数: 0 h-index: 0机构: Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USAGlen, H.论文数: 0 引用数: 0 h-index: 0机构: Beatson West Scotland Canc Ctr, Med Oncol, Glasgow, Lanark, Scotland Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USAMichaelson, M. D.论文数: 0 引用数: 0 h-index: 0机构: Massachusetts Gen Hosp, Hematol Oncol, Boston, MA 02114 USA Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USALarkin, J.论文数: 0 引用数: 0 h-index: 0机构: Royal Marsden NHS Hosp, Dept Med Oncol, London, England Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USAMinoshima, Y.论文数: 0 引用数: 0 h-index: 0机构: Eisai & Co Ltd, Ibaraki, Japan Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USAKanekiyo, M.论文数: 0 引用数: 0 h-index: 0机构: Eisai & Co Ltd, Ibaraki, Japan Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USADairiki, R.论文数: 0 引用数: 0 h-index: 0机构: Eisai & Co Ltd, Ibaraki, Japan Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USASachdev, P.论文数: 0 引用数: 0 h-index: 0机构: Eisai Inc, Oncol Business Grp, Woodcliff Lake, NJ USA Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USADutcus, C. E.论文数: 0 引用数: 0 h-index: 0机构: Eisai Inc, Oncol Business Grp, Woodcliff Lake, NJ USA Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USAFunahashi, Y.论文数: 0 引用数: 0 h-index: 0机构: Eisai & Co Ltd, Ibaraki, Japan Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USAVoss, M. H.论文数: 0 引用数: 0 h-index: 0机构: Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA
- [39] Phase I study of gemcitabine plus bortezomib in elderly patients with solid tumors.CANCER RESEARCH, 2009, 69Bommakanti, Satya论文数: 0 引用数: 0 h-index: 0机构: Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN USA Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN USAGada, Purvi论文数: 0 引用数: 0 h-index: 0机构: Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN USA Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN USA论文数: 引用数: h-index:机构:
- [40] Phase I dose-escalation study of sorafenib plus S-1 in refractory solid tumors.JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (04)Tsai, Hui-Jen论文数: 0 引用数: 0 h-index: 0机构: Natl Hlth Res Inst, Tainan, TaiwanChiang, Nai-Jung论文数: 0 引用数: 0 h-index: 0机构: Natl Hlth Res Inst, Tainan, TaiwanShiah, Her-Shyong论文数: 0 引用数: 0 h-index: 0机构: Natl Hlth Res Inst, Tainan, TaiwanChang, Kwang-Yu论文数: 0 引用数: 0 h-index: 0机构: Natl Hlth Res Inst, Tainan, TaiwanSu, Wu-Chou论文数: 0 引用数: 0 h-index: 0机构: Natl Hlth Res Inst, Tainan, TaiwanChang, Jang-Yang论文数: 0 引用数: 0 h-index: 0机构: Natl Hlth Res Inst, Tainan, TaiwanChen, Li-Tzong论文数: 0 引用数: 0 h-index: 0机构: Natl Hlth Res Inst, Tainan, Taiwan