Recent Advances on Drug-Loaded Mesenchymal Stem Cells With Anti-neoplastic Agents for Targeted Treatment of Cancer

被引：79

作者：

Babajani, Amirhesam ^{[1
,2
]}

Soltani, Pegah ^{[2
]}

Jamshidi, Elham ^{[1
,3
]}

Farjoo, Mohammad Hadi ^{[1
]}

Niknejad, Hassan ^{[1
]}

机构：

[1] Shahid Beheshti Univ Med Sci, Sch Med, Dept Pharmacol, Tehran, Iran

[2] Shahid Beheshti Univ Med Sci, Sch Med, Student Res Comm, Tehran, Iran

[3] Shahid Beheshti Univ Med Sci, Student Res Comm, Sch Pharm, Tehran, Iran

来源：

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY | 2020年 / 8卷

关键词：

mesenchymal stem cell; cancer; chemotherapeutic drugs; targeted therapy; angiogenesis; metastasis; apoptosis; proliferation; IN-VITRO PROLIFERATION; STROMAL CELLS; BONE-MARROW; ADIPOSE-TISSUE; INHIBIT PROLIFERATION; GROWTH-FACTOR; TUMOR-GROWTH; DELIVERY; PACLITAXEL; DIFFERENTIATION;

D O I：

10.3389/fbioe.2020.00748

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Mesenchymal stem cells (MSCs), as an undifferentiated group of adult multipotent cells, have remarkable antitumor features that bring them up as a novel choice to treat cancers. MSCs are capable of altering the behavior of cells in the tumor microenvironment, inducing an anti-inflammatory effect in tumor cells, inhibiting tumor angiogenesis, and preventing metastasis. Besides, MSCs can induce apoptosis and inhibit the proliferation of tumor cells. The ability of MSCs to be loaded with chemotherapeutic drugs and release them in the site of primary and metastatic neoplasms makes them a preferable choice as targeted drug delivery procedure. Targeted drug delivery minimizes unexpected side effects of chemotherapeutic drugs and improves clinical outcomes. This review focuses on recent advances on innate antineoplastic features of MSCs and the effect of chemotherapeutic drugs on viability, proliferation, and the regenerative capacity of various kinds of MSCs. It also discusses the efficacy and mechanisms of drug loading and releasing procedures along within vivoandin vitropreclinical outcomes of antineoplastic effects of primed MSCs for clinical prospection.

引用

页数：19

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