Orally Administered Polysaccharide Derived from Blackcurrants (Ribes nigrum L.) Improves Skin Hydration in Ultraviolet-Irradiated Hairless Mice

被引：4

作者：

Ashigai, Hiroshi ^{[1
]}

Komano, Yuta ^{[1
]}

Wang, Guanying ^{[1
]}

Kawachi, Yasuji ^{[1
]}

Sunaga, Kazuko ^{[2
]}

Yamamoto, Reiko ^{[3
]}

Takata, Ryoji ^{[3
]}

Yanai, Takaaki ^{[3
]}

机构：

[1] Kirin Co Ltd, Res Labs Hlth Sci & Food Technol, Tsurumi Ku, 1-17-1 Namamugi, Yokohama, Kanagawa 2308628, Japan

[2] Mercian Corp, Mkt Dept, Nakano Ku, 4-10-2 Nakano, Tokyo 1640001, Japan

[3] Kirin Co Ltd, Res Labs Wine Technol, 4-9-1 Johnan, Fujisawa, Kanagawa 2510057, Japan

来源：

JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY | 2018年 / 64卷 / 04期

关键词：

blackcurrant; polysaccharide; ultraviolet; skin hydration; ANTITUMOR-ACTIVITY; STRATUM-CORNEUM; RADIATION; INTERLEUKIN-10; SUPPRESSION; INHIBITION;

D O I：

10.3177/jnsv.64.301

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Blackcurrants (Ribes nigruni L.) have various benefits for human health. In particular, a polysaccharide derived from blackcurrant was found to be an immunostimulating food ingredient in a mouse model. We named a polysaccharide derived from blackcurrant cassis polysaccharide (CAPS). In a previous clinical study, we reported that CAPS affects skin dehydration, demonstrating its effectiveness against skin inflammation was related to atopic dermatitis; skin inflammation caused skin dehydration. However, there are no studies regarding CAPS effectiveness against skin dehydration. The current study aimed to investigate CAPS effectiveness against skin dehydration. We further demonstrate the effect of oral administration of CAPS on skin dehydration caused by ultraviolet (UV) irradiation-induced inflammation in mice. We found that CAPS administration suppresses skin dehydration caused by UV irradiation. We also found that CAPS decreases interleukin-6 and matrix metalloproteinase transcription levels in the mouse skin. These results show that CAPS improves skin hydration in UV-irradiated mice.

引用

页码：301 / 304

页数：4

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