Cellulose phosphates as biomaterials.: II.: Surface chemical modification of regenerated cellulose hydrogels

被引:35
|
作者
Granja, PL
Pouységu, L
Deffieux, D
Daudé, G
De Jéso, B
Labrugére, C
Baquey, C
Barbosa, MA
机构
[1] INEB, Lab Biomat, P-4150180 Oporto, Portugal
[2] Univ Porto, Fac Engn, Dept Mat & Met Engn, P-4100 Oporto, Portugal
[3] Univ Bordeaux 1, Lab Chim Subst Vegetales, Inst Pin, F-33405 Talence, France
[4] Univ Bordeaux 1, ICMCB, CNRS, UPR 9048,CeCaMA, F-33600 Pessac, France
[5] Univ Bordeaux 2, INSERM, U443, F-33076 Bordeaux, France
关键词
cellulose phosphates; biomaterials; phosphorylation; H3PO4/P2O5/Et3PO4/hexanol method; surface modification;
D O I
10.1002/app.2194
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Cellulose regenerated by the viscose process was previously investigated as an implantable material in orthopedic surgery. It was envisaged to take advantage not only of its good matching with mechanical properties of bone but also of its hydroexpansivity, therefore allowing a satisfactory fixation to hard tissue. Both the osteoconduction and the lack of osteoinduction of this material were demonstrated. Grafting of phosphate groups was then envisaged as the means to render cellulose more suitable for orthopedic applications by enhancing its bioactivity. In the present work, the previously optimized phosphorylation reaction was successfully adapted to the surface modification of regenerated cellulose. Modified materials were characterized by XPS, FTIR, and P-31 MAS NMR spectroscopic studies, and contact angle measurements, revealing the chemical bond between phosphate groups and cellulose, as well as the hydrophilic nature of phosphorylated materials, which increases with increasing phosphate contents. Water swelling and resistance to gamma sterilization were assessed as well, showing that phosphorylated materials swell considerably in water and were not affected when sterilization was carried out under a nitrogen atmosphere. The increase in surface roughness attributed to chemical modification was demonstrated through laser rugosimetry measurements. (C) 2001 John Wiley & Sons, Inc.
引用
收藏
页码:3354 / 3365
页数:12
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